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Effect of adjunctive diode laser in the non-surgical periodontal treatment in patients with diabetes mellitus: a systematic review and meta-analysis

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Abstract

This study aimed to systematically review and analyze the present randomized clinical trials (RCTs) regarding the clinical efficacy of a diode laser (DL) adjuvant to scaling and root planning (SRP) in patients with chronic periodontitis (CP) who have diabetes mellitus (DM). Five databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trails, Web of Science, and Chinese BioMedical Literature Databases) were searched. A meta-analysis was implemented to evaluate periodontal parameters including probing depth (PD) and clinical attachment level (CAL) as primary outcomes. Hemoglobin A1c (HbA1c), plaque index (PI), and the gingival index (GI) were also observed as secondary outcomes. Independent scanning of 239 papers resulted in 9 RCTs. Moderate evidence demonstrated that the test groups showed significant benefits for PD reduction, CAL gain, and HbA1c reduction after 3 and 6 months. Significant differences in PI and GI reduction were not found except for GI reduction within 1 month. The collective evidence suggested that the DL with SRP had significant improvements in clinical results compared to SRP alone. Based on our results, the DL could be a recommended therapy for patients with CP who have DM.

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Funding

This study was supported by the National Natural Science Foundation of China (81870779).

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  1. Pengfei Zhao and Xiuxiu Song contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China

    Pengfei Zhao, Xiuxiu Song, Qian Wang, Peng Zhang, Lulingxiao Nie, Yi Ding & Qi Wang

  2. Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, 14#, 3rd Section S Renmin Road, Chengdu, 610041, China

    Pengfei Zhao, Xiuxiu Song, Qian Wang, Peng Zhang, Lulingxiao Nie & Qi Wang

  3. Department of Periodontology, West China Hospital of Stomatology, Sichuan University, Chengdu, China

    Yi Ding

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  1. Pengfei Zhao
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Zhao, P., Song, X., Wang, Q. et al. Effect of adjunctive diode laser in the non-surgical periodontal treatment in patients with diabetes mellitus: a systematic review and meta-analysis. Lasers Med Sci 36, 939–950 (2021). https://doi.org/10.1007/s10103-020-03208-7

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