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Maximal oxygen uptake and exercise tolerance are improved in rats with heart failure subjected to low-level laser therapy associated with resistance training

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Abstract

Exercise tolerance and maximal oxygen uptake (VO2max) are reduced in heart failure (HF). The influence of combined resistance training (RT) and low-level laser therapy (LLLT) on exercise tolerance and VO2max in HF has not yet been explored. The aim of this study was to evaluate the influence of combined RT and LLLT on VO2max and exercise tolerance in rats with HF induced by myocardial infarction (MI). Rats were allocated to sedentary sham (Sed-Sham, n = 12), sedentary heart failure (Sed-HF, n = 9), RT heart failure (RT-HF, n = 7) and RT associated with LLLT heart failure (RT + LLLT-HF, n = 7) groups. After MI or sham surgery, rats underwent a RT and LLLT protocol (applied immediately after RT) for 8 weeks. VO2max and exercise tolerance were evaluated at the end of protocol. HF rats subjected to LLLT combined with RT showed higher VO2basal (41 %), VO2max (40 %), VO2reserve (39 %), run distance (46 %), time to exhaustion (30 %) and maximal velocity (22 %) compared with HF rats that underwent RT alone. LLLT associated with RT improved oxygen uptake and exercise tolerance compared with RT alone in HF rats.

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Acknowledgments

We are thankful to Prof. Edson Quagliotto, Prof. Ramiro Barcos Nunes and Ignês Cristiane de Souza Paiva for their support during the development of this study. This work was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brazil, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil, and Fundação de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS), Brazil.

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  1. Laboratório de Fisiologia, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil

    Vítor Scotta Hentschke, Lucas Capalonga, Douglas Dalcin Rossato, Júlia Luíza Perini, Jadson Pereira Alves, Giuseppe Potrick Stefani, Marlus Karsten & Pedro Dal Lago

  2. Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil

    Vítor Scotta Hentschke, Jadson Pereira Alves & Giuseppe Potrick Stefani

  3. Centro Universitário Franciscano (UNIFRA), Santa Maria, Rio Grande do Sul, Brazil

    Douglas Dalcin Rossato

  4. Departamento de Fisioterapia, Universidade do Estado de Santa Catarina (UDESC), Florianópolis, Santa Catarina, Brazil

    Marlus Karsten

  5. Departamento de Farmacociências, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil

    Mauro Pontes

  6. Departamento de Fisioterapia, Universidade Federal de Ciências da Saúde de Porto Alegre – UFCSPA, Rua Sarmento Leite, 245, 90050-170, Porto Alegre, RS, Brazil

    Pedro Dal Lago

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  1. Vítor Scotta Hentschke
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This study was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).

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All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.

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Hentschke, V.S., Capalonga, L., Rossato, D.D. et al. Maximal oxygen uptake and exercise tolerance are improved in rats with heart failure subjected to low-level laser therapy associated with resistance training. Lasers Med Sci 32, 73–85 (2017). https://doi.org/10.1007/s10103-016-2088-3

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