Abstract
Background
Uric acid is a natural antioxidant, and low levels of uric acid have been reported to be a potential risk factor in the development of nervous system diseases. Herein, we investigated whether uric acid levels play a role in trigeminal neuralgia (TN).
Methods
We conducted a cohort study to compare the serum uric acid levels of patients with TN and healthy controls. We also analyzed the impact of uric acid levels on the risk of TN and symptom severity.
Results
In comparison to control participants (n = 133), uric acid levels were remarkably decreased in patients with TN (n = 181). Uric acid (OR = 0.989; 95% CI 0.986–0.993; P < 0.001) was also determined as a protective factor against TN based on multivariate logistic regression models. Furthermore, nonlinear relationships between serum uric acid levels and TN incidence rate and between that and the Barrow Neurological Institute (BNI) grading were observed.
Conclusions
Our study is the first to show a relationship between serum uric acid levels and TN. Specifically, low serum uric acid levels were associated with an increased risk of TN and more severe clinical symptoms. We expect that these findings will provide new insights into the prevention and treatment of TN.
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Acknowledgements
We would like to thank Editage for English language editing. Thank you to every patient who participated in the study.
Funding
Doctoral Research Fund of the First Affiliated Hospital of USTC (No: RC2021121).
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BWC and XZW jointly completed the experiment and the writing; PC and CN assisted in the writing and followed up patients. HCG and CSN took overall control of the whole study. All authors contributed to the article and approved the submitted version.
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The Institutional Ethics Committee of the First Affiliated Hospital of USTC approved the study protocol.
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The authors declare no competing interests.
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Chang, B., Wang, X., Chen, P. et al. Low serum uric acid levels are associated with incidence and severity in trigeminal neuralgia. Neurol Sci 43, 6053–6058 (2022). https://doi.org/10.1007/s10072-022-06223-4
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DOI: https://doi.org/10.1007/s10072-022-06223-4