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A simple measure of cognitive reserve is relevant for cognitive performance in MS patients

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Abstract

Cognitive reserve (CR) contributes to preserve cognition despite brain damage. This theory has been applied to multiple sclerosis (MS) to explain the partial relationship between cognition and MRI markers of brain pathology. Our aim was to determine the relationship between two measures of CR and cognition in MS. One hundred and forty-seven MS patients were enrolled. Cognition was assessed using the Rao’s Brief Repeatable Battery and the Stroop Test. CR was measured as the vocabulary subtest of the WAIS-R score (VOC) and the number of years of formal education (EDU). Regression analysis included raw score data on each neuropsychological (NP) test as dependent variables and demographic/clinical parameters, VOC, and EDU as independent predictors. A binary logistic regression analysis including clinical/CR parameters as covariates and absence/presence of cognitive deficits as dependent variables was performed too. VOC, but not EDU, was strongly correlated with performances at all ten NP tests. EDU was correlated with executive performances. The binary logistic regression showed that only the Expanded Disability Status Scale (EDSS) and VOC were independently correlated with the presence/absence of CD. The lower the VOC and/or the higher the EDSS, the higher the frequency of CD. In conclusion, our study supports the relevance of CR in subtending cognitive performances and the presence of CD in MS patients.

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Authors and Affiliations

  1. Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania “Luigi Vanvitelli”, Piazza Luigi Miraglia, 2, 80138, Naples, Italy

    Marida Della Corte, Alvino Bisecco, Rosaria Sacco, Mattia Siciliano, Alessandro d’Ambrosio, Renato Docimo, Luigi Lavorgna, Simona Bonavita, Gioacchino Tedeschi & Antonio Gallo

  2. MRI-Center “SUN-FISM”, University of Campania “Luigi Vanvitelli” and Institute of Diagnosis and Care “Hermitage-Capodimonte”, Naples, Italy

    Marida Della Corte, Gabriella Santangelo, Alvino Bisecco, Simona Bonavita, Gioacchino Tedeschi & Antonio Gallo

  3. Department of Psychology, University of Campania “Luigi Vanvitelli”, Caserta, Italy

    Gabriella Santangelo & Mattia Siciliano

  4. Department of Neurology, “Umberto I” Hospital, Nocera Inferiore, SA, Italy

    Teresa Cuomo

Authors
  1. Marida Della Corte
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  2. Gabriella Santangelo
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  3. Alvino Bisecco
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  4. Rosaria Sacco
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  6. Alessandro d’Ambrosio
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  7. Renato Docimo
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  8. Teresa Cuomo
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  9. Luigi Lavorgna
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  10. Simona Bonavita
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  11. Gioacchino Tedeschi
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  12. Antonio Gallo
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Correspondence to Antonio Gallo.

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Della Corte, M., Santangelo, G., Bisecco, A. et al. A simple measure of cognitive reserve is relevant for cognitive performance in MS patients. Neurol Sci 39, 1267–1273 (2018). https://doi.org/10.1007/s10072-018-3422-2

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  • DOI: https://doi.org/10.1007/s10072-018-3422-2

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