Abstract
Experimental autoimmune neuritis (EAN) is a well-known animal model of human demyelinating polyneuropathies. Macrophages are the major immune cells in peripheral nerves and may exert tissue-damage or tissue-protective activity during EAN. While considered to define a subpopulation of T lymphocytes, CD8 expression has been found on certain macrophages that show cytotoxic effects. Here we have studied the spatiotemporal accumulation of CD8+ cells in sciatic nerves of EAN rats. A robust accumulation of CD8+ cells was observed in the sciatic nerves of EAN rats, which was positively correlated with the severity of neurological signs in EAN. Moreover, double-labelling experiments showed that the major cellular sources of CD8 were reactive macrophages. Therefore, our data here suggest a pathological role of CD8+ macrophages in EAN, which makes CD8+ macrophage a potential therapeutic target for EAN.
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Z.-M. Zhang and R. Shi are joint first authors.
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Zhang, ZM., Shi, R., Chen, H. et al. Lesional accumulation of CD8+ cells in sciatic nerves of experimental autoimmune neuritis rats. Neurol Sci 37, 199–203 (2016). https://doi.org/10.1007/s10072-015-2384-x
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DOI: https://doi.org/10.1007/s10072-015-2384-x