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Antioxidant and lipid-reducing effects of Rosa rugosa root extract in 3T3-L1 cell

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Abstract

Rosa rugosa root is traditionally known to be effective in the treatment of diabetes in Korea. R. rugosa root-specific compounds also show antioxidant effects, and could reduce lipid and fat accumulation, however, the underlying mechanism has not been clarified. In present study, the antioxidant and lipid-reducing effects of a 50% ethanol extract of R. rugosa (REE) were investigated differentiated mouse preadipocytes (3T3-L1 cells). REE showed strong radical scavenging activities and inhibitory effect of total lipid accumulation and triglyceride levels in differentiated 3T3-L1 cells. In addition, REE treatment reduced the mRNA and protein levels of adipogenesis and lipogenesis markers. This REE-promoted lipid reduction was caused by downregulation of peroxisome proliferator activated receptor gamma (PPARγ), CCAAT/enhancer binding protein alpha (C/EBPα), and sterol regulatory element binding protein1 (SREBP1c) and down regulation of ERK expression. Overall, these results demonstrate the potential of REE for development of a drug in the medical treatment of lipid-associated disorders.

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Acknowledgements

The present study was supported by the Chuncheon Bioindustry Foundation, Chuncheon, Republic of Korea, 2020–2021.

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  1. Department of Research and development, Chuncheon Bioindustry Foundation, Chuncheon, 24232, Republic of Korea

    Da-Hye Choi, Joon-Hee Han, Min Hong, Sun-Yeop Lee, Soo-Ung Lee & Tae-Hyung Kwon

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  1. Da-Hye Choi
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  2. Joon-Hee Han
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  3. Min Hong
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Correspondence to Tae-Hyung Kwon.

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Choi, DH., Han, JH., Hong, M. et al. Antioxidant and lipid-reducing effects of Rosa rugosa root extract in 3T3-L1 cell. Food Sci Biotechnol 31, 121–129 (2022). https://doi.org/10.1007/s10068-021-01018-3

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