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Antidiabetic effect of an extract of nutricultured Brassica napus containing vanadium from a Jeju water concentrate

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Abstract

The purpose of this study was to determine the antidiabetic effect of an extract of nutricultured Brassica napus containing vanadium (BECV). The BECV was prepared following nutriculture of B. napus with a Jeju water vanadium concentrate for 7 day. The BECV was administered to db/db mice for 8 weeks at different dosages (0.028, 0.14, and 0.7 μg/kg; as vanadium concentration in BECV). After 8 weeks, the BECV results showed mouse blood glucose concentrations to significantly decrease, in a dose-dependent manner, compared with the results for control mice. In addition, the concentrations of triglyceride, total cholesterol, and glycated hemoglobin were significantly lower after 8 weeks of administration of 0.7 μg/kg BECV. Therefore, the BECV may have protective effects against type 2 diabetes.

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References

  • Ashiq U, Jamal RA, Mahroof-Tahir M, Maqsood ZT, Khan KM, Omer I, Choudhary MI. Enzyme inhibition, radical scavenging, and spectroscopic studies of vanadium(IV)-hydrazide complexes. J. Enzym. Inh. Med. Chem. 24: 1336–1343 (2009)

    Article  CAS  Google Scholar 

  • Bendayan M, Gingras D. Effects of vanadate administration on blood glucose and insulin levels as well as on the exocrine pancreatic function in streptozotocindiabetic rats. Diabetologia. 32: 561–567 (1989)

    Article  CAS  Google Scholar 

  • Bhuiyan MS, Fukunaga K. Cardioprotection by vanadium compounds targeting Akt-mediated signaling. J Pharmacol Sci. 110: 1–13 (2009)

    Article  CAS  Google Scholar 

  • Bollen M, Miralpeix M, Ventura F, Toth B, Bartrons R, Stalmans W. Oral administration of vanadate to streptozotocin-diabetic rats restores the glucose-induced activation of liver glycogen synthase. Biochem. J. 267: 269–271 (1990)

    Article  CAS  Google Scholar 

  • Bornfeldt KE, Tabas I. Insulin resistance, hyperglycemia, and atherosclerosis. Cell Metab. 14: 575–585 (2011)

    Article  CAS  Google Scholar 

  • Brichard SM, Bailey CJ, Henquin JC. Marked improvement of glucose homeostasis in diabetic ob/ob mice given oral vanadate. Diabetes. 39: 1326–1332 (1990)

    Article  CAS  Google Scholar 

  • Brichard SM, Lederer J, Henquin JC. The insulin-like properties of vanadium: A curiosity or a perspective for the treatment of diabetes? Diabete Metab. 17: 435–440 (1991)

    CAS  PubMed  Google Scholar 

  • Brichard SM, Pottier AM, Henquin JC. Long term improvement of glucose homeostasis by vanadate in obese hyperinsulinemic fa/fa rats. Endocrinology. 125: 2510–2516 (1989)

    Article  CAS  Google Scholar 

  • Domingo JL, Gomez M, Sanchez DJ, Llobet JM, Keen CL. Toxicology of vanadium compounds in diabetic rats: The action of chelating agents on vanadium accumulation. Mol. Cell. Biochem. 153: 233–240 (1995)

    Article  CAS  Google Scholar 

  • Eledrisi MS, Alshanti MS, Shah MF, Brolosy B, Jaha N. Overview of the diagnosis and management of diabetic ketoacidosis. Afr J Med Sci. 331: 243–251 (2006)

    Article  Google Scholar 

  • Florkowski C. HbA1c as a diagnostic test for diabetes mellitus-reviewing the evidence. Clin Biochem Rev. 34: 75–83 (2013)

    PubMed  PubMed Central  Google Scholar 

  • Ghosh S, Suryawanshi SA. Effect of vinca rosea extracts in treatment of alloxan diabetes in male albino rats. Indian J. Ex. Biol. 39: 748–758 (2001)

    CAS  Google Scholar 

  • Greer JJ, Ware DP, Lefer DJ. Myocardial infarction and heart failure in the db/db diabetic mouse. Am. J. Physiol Heart Circ Physiol. 290: H146–H153 (2006)

    Article  CAS  Google Scholar 

  • Heyliger CE, Tahiliani AG, McNeill JH. Effect of vanadate on elevated glucose and depressed cardiac performance of diabetic rats. Science. 227: 1474–1477 (1985)

    Article  CAS  Google Scholar 

  • Hwang SL, Chang HW. Natural vanadium-containing Jeju ground water stimulates glucose uptake through the activation of AMP-activated protein kinase in L6 myotubes. Mol. Cell. Biochem. 360: 401–409 (2012)

    Article  CAS  Google Scholar 

  • McNeill JH, Yuen VG, Hoveyda HR, Orvig C. Bis(maltolato)-oxovanadium (IV) is a potent insulin mimic. Med. Chem. 35: 1489–1491 (1992)

    Article  CAS  Google Scholar 

  • Meyerovitch I, Farfel Z, Sack J, Shechter Y. Oral administration of vanadate normalizes blood glucose levels in streptozotocin-treated rats. J. Biol. Chem. 262: 6658–6662 (1987)

    CAS  PubMed  Google Scholar 

  • Meyerovitch J, Rothenberg P, Shechter Y, Bonner-Weir S, Kahn CR. Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus. J. Clin. Invest. 87: 1286–1294 (1991)

    Article  CAS  Google Scholar 

  • Nyane NA, Tlaila TB, Malefane TG, Ndwandwe DE. Owira PO. Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights. Eur. J. Pharmacol. 803: 103–111 (2017)

    Article  Google Scholar 

  • Park SJ, Youn CK, Hyun JW, You HJ. The anti-obesity effect of natural vanadium-containing Jeju ground water. Biol. Trace. Elem. Res. 151: 294–300 (2013)

    Article  CAS  Google Scholar 

  • Patel DK, Prasad SK, Kumar R, Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed. 2: 320–330 (2012)

    Article  CAS  Google Scholar 

  • Posner BI, Faure R, Burgess JW, Bevan AP, Lachance D, Zhang-Sun G, Fantus IG, Ng JB, Hall DA, Lum BS, Shaver A. Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. J. Biol. Chem. 269: 4596–4604 (1994)

    CAS  PubMed  Google Scholar 

  • Poucheret P, Verma S, Grynpas MD, McNeill JH. Vanadium and diabetes. Mol. Cell. Biochem. 188: 73–80 (1998)

    Article  CAS  Google Scholar 

  • Pugazhenthi S, Angel JF, Khandelwal RL. Long-term effects of vanadate treatment on glycogen metabolizing and lipogenic enzymes of liver in genetically diabetic (db/db) mice. Metabolism. 40: 941–946 (1991)

    Article  CAS  Google Scholar 

  • Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats. Diabetes Res. Clinl. Practice. 62: 139–148 (2003)

    Article  Google Scholar 

  • Ramanadham S, Mongold JJ, Brownsey RW, Cros GH, McNeill JH. Oral vanadyl sulfate in treatment of diabetes mellitus in rats. Am. J. Physiol. 257: H904–H911 (1989)

    CAS  PubMed  Google Scholar 

  • Rao BK, Kesavulu MM, Apparao C. Antihyperglycemic activity of Momordica cymbalaria in alloxan diabetic rats. J. Ethnopharmacol. 78: 67–71 (2001)

    Article  CAS  Google Scholar 

  • Reul BA, Amin SS, Buchet JP, Ongemba LN, Crans DC, Brichard SM. Effects of vanadium complexes with organic ligands on glucose metabolism: a comparison study in diabetic rats. Brit. J. Pharmacol. 126: 4674–4677 (1999)

    Article  Google Scholar 

  • Sakurai H, Tsuchiya K, Nukatsuka M, Sofue M,- Kawada J. Insulin-like effects of vanadyl ion in streptozotocin-induced diabetic rats. J. Endocrinol. 126: 451–459 (1990)

    Article  CAS  Google Scholar 

  • Sekar N, Kanthasamy A, William S, Balasubramaniya N, Govindasamy S. Antioxidant effect of vanadate on experimental diabetic rats. Acta Diabetol. Lat. 27: 285–293 (1990)

    Article  CAS  Google Scholar 

  • Sekar N, Kanthasamy A, William S, Subramanian S, Govindasamy S. Insulin actions of vanadate in diabetic rats. Pharmacol. Res. 22: 207–217 (1989)

    Article  Google Scholar 

  • Shisheva A, Ikonomov O, Shechter Y. The protein tyrosine phosphatase inhibitor, pervanadate, is a powerful antidiabetic agent in streptozotocin-treated diabetic rats. Endocrinology. 134: 507–510 (1994)

    Article  CAS  Google Scholar 

  • Srivastava AK. Section Review-Oncologic, Endocrine & Metabolic:Potential use of vanadium compounds in the treatment of diabetes mellitus. Expert Opin. Investig. Drugs. 4: 525–536 (1995)

    Article  CAS  Google Scholar 

  • Strout HV, Vicario PP, Biswas C, Superstein R, Brady EJ, Pilch PF, Berger J. Vanadate treatment of streptozotocin diabetic rats restores expression of the insulin responsive glucose transporter in skeletal muscle. Endocrinology. 126: 2728–2732 (1990)

    Article  CAS  Google Scholar 

  • Vigneri R, Goldfine, ID. Role of metformin in treatment of diabetes mellitus. Diabetes Care. 10: 118–122 (1987)

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This research was financially supported by the Ministry of Trade, Industry & Energy (MOTIE), Korea Institute for Advancement of Technology (KIAT) and Jeju Institute for Regional Program Evaluation (GWIRPE) through the Leading Industry Development for Economic Region [No. R0000359].

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Authors and Affiliations

  1. Hurum Central Research Institute Co., Ltd., Seogwipo, 63608, Republic of Korea

    Ji-Hyun Yun, Sung-Hwan Park, Goo-Hee Choi, In-Jae Park & Ju-Hyun Cho

  2. Department of Food Science and Biotechnology, Kangwon National University, Chuncheon, 24341, Republic of Korea

    Jin-Ha Lee & Ok-Hwan Lee

  3. Department of Culinary Arts, Jeju Tourism University, Jeju, 63063, Republic of Korea

    Jung-Hyon Kim

  4. EBO Co., Ltd., Cheongju, 28116, Republic of Korea

    Yun-Hee Seo

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  1. Ji-Hyun Yun
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Correspondence to Ju-Hyun Cho.

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Yun, JH., Park, SH., Choi, GH. et al. Antidiabetic effect of an extract of nutricultured Brassica napus containing vanadium from a Jeju water concentrate. Food Sci Biotechnol 28, 209–214 (2019). https://doi.org/10.1007/s10068-018-0436-8

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  • DOI: https://doi.org/10.1007/s10068-018-0436-8

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