Abstract
This study investigated the anti-obesity effects of Jeju ground water containing the vanadium components S1 (8.0 ± 0.9 μg/l) and S3 (26.0 ± 2.09 μg/l) on the differentiation of 3 T3-L1 preadipocytes and obesity in mice that were fed a high-fat diet (HFD). The 3 T3-L1 preadipocyte cells were cultured and differentiated in media consisting of Jeju ground water (S1, S3) or deionized water (DW) containing dexamethasone, isobutylmethylxanthine, and insulin. Oil Red O staining showed that lipid accumulation was attenuated in adipocyte cells treated with Jeju ground water. S3 significantly decreased peroxisome-activated receptor γ and CCAAT-enhancer-binding protein α mRNA expression levels, which play major roles in the transcriptional control of adipogenesis, compared to DW. Furthermore, mRNA expression levels of targeted genes, such as adipocyte fatty acid, lipoprotein lipase, and leptin, were decreased by S3 treatment compared with the control group. In mice with HFD-induced obesity, Jeju ground water decreased HFD-induced body weight gain and reduced total cholesterol, triglyceride, and glucose levels in the plasma compared to control mice. Taken together, Jeju ground water inhibits preadipocyte differentiation and adipogenesis in obesity animal models.
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This research was financially supported by the Ministry of Knowledge Economy (MKE), Korea Institute for the Advancement of Technology (KIAT), and Jeju Leading Industry Office through the Leading Industry Development for Economic Region.
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Park SJ and Youn CK contributed equally to this study.
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Park, SJ., Youn, CK., Hyun, J.W. et al. The Anti-obesity Effect of Natural Vanadium-Containing Jeju Ground Water. Biol Trace Elem Res 151, 294–300 (2013). https://doi.org/10.1007/s12011-012-9557-8
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DOI: https://doi.org/10.1007/s12011-012-9557-8