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Trans vaccenic acid (trans-11 18:1), a precursor of cis-9, trans-11-conjugated linoleic acid, exerts a direct anti-carcinogenic function in T47D breast carcinoma cells

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Abstract

The role of TVA in suppressing proliferation of various human cancer cell lines was investigated that TVA and c9, t11-CLA both suppressed cell proliferation. The suppressive effect of TVA was clearly observed in T47D breast carcinoma cells after stearoyl-CoA desaturase-1 (SCD) knockdown using small interfering RNA (siRNA), demonstrating TVA directly affects suppression of human breast carcinogenesis.

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Authors and Affiliations

  1. Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul, 143-701, Korea

    Jae-Sung Lee, Ji-Na Lim & Hong-Gu Lee

  2. Natural Product Clinical Research Center, Clinical Research Center, Busan, 602-739, Korea

    Jin-Ju Oh

  3. Department of Biology, Kyung Hee University, Seoul, 130-701, Korea

    Sang-Hun Kim

  4. College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130-118, China

    Tao Wang

  5. Key Laboratory of Animal Nutrition and Feed Science, Jilin Province, Jilin Agricultural University, Changchun, 130-118, China

    Tao Wang

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  1. Jin-Ju Oh
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  2. Jae-Sung Lee
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Correspondence to Hong-Gu Lee.

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Oh, JJ., Lee, JS., Lim, JN. et al. Trans vaccenic acid (trans-11 18:1), a precursor of cis-9, trans-11-conjugated linoleic acid, exerts a direct anti-carcinogenic function in T47D breast carcinoma cells. Food Sci Biotechnol 23, 641–646 (2014). https://doi.org/10.1007/s10068-014-0087-3

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  • DOI: https://doi.org/10.1007/s10068-014-0087-3

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