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Sex-specific differences in patients with psoriatic arthritis:a nationwide study from the Chinese Registry of Psoriatic Arthritis (CREPAR IV)

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Abstract

Objectives

To elucidate the sex-specific differences in demographic features, clinical characteristics, and quality of life in Chinese patients with psoriatic arthritis (PsA).

Methods

A total of 1,074 patients with PsA registered between December 2018 and June 2021 from the Chinese REgistry of Psoriatic ARthritis (CREPAR) cohort were selected. The baseline data on demographics, clinical characteristics, commonly used laboratory tests, comorbidities, and quality of life assessments were collected for this cross-sectional analysis.

Results

A total of 1,074 patients were included in this study, 585 (54.47%) of them were male and 489 (45.53%) were female. The age at PsA onset in male patients was earlier than that in female patients (38.10 ± 12.79 vs 40.37 ± 13.41, p = 0.005). For clinical characteristics, male patients presented with higher rates of axial involvement (43.89% vs 37.74%, p = 0.044) and nail involvement (66.15% vs 58.08%, p = 0.006), while female patients presented with higher rates of peripheral arthritis (89.57% vs 83.93%, p = 0.007). For laboratory tests, men presented with a higher percentage of HLA-B27 positivity than women (24.65% vs 16.70%, p = 0.002) and had higher levels of CRP (median 9.70 vs 5.65, p < 0.001). Regarding disease assessment indices, male patients scored higher in PASI and BASFI (median 5.00 vs 3.00, p = 0.007 and 1.80 vs 1.40, p = 0.012, respectively). No sex difference was found in rates of achieving remission. Factors associated with disease remission were also analyzed in both sexes.

Conclusion

Demographic and clinical characteristics tend to vary between male and female patients with PsA. Male patients reported more functional limitations in daily life.

Key Points

• The demographic and clinical features vary greatly between male and female patients with PsA.

• Male patients reported more functional burden in daily life as measured by BASFI.

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Data Availability

The data used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

This study was supported by a grant from the National Basic Research Program of China (973 Program) (No.2014CB541801).

Author information

Authors and Affiliations

  1. Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, No. 1 Shuaifuyuan, Wangfujing Ave, Beijing, 100730, China

    Shihao He, Fan Yang, Chaofan Lu, Jinmei Su, Mengtao Li, Xiaomei Leng & Xiaofeng Zeng

  2. Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences; School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China

    Yanhong Wang

  3. Department of Rheumatology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China

    Xinwang Duan

  4. Department of Rheumatology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China

    Hongbin Li

  5. Department of Rheumatology, The People’s Hospital of the Xinjiang Uygur Autonomous Region, Urumqi, 830001, Xinjiang, China

    Lijun Wu

  6. Department of Rheumatology, First Affiliated Hospital of Baotou Medical College, Baotou, 014010, Inner Mongolia, China

    Yongfu Wang

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  1. Shihao He
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on behalf of Chinese Registry of Psoriatic Arthritis (CREPAR)

Corresponding authors

Correspondence to Xiaomei Leng or Xiaofeng Zeng.

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Ethical standards

Ethical approval was obtained from the Peking Union Medical College Hospital (PUMCH) Ethics Board (S-K1811). The other centers participating in CREPAR also obtained their ethical approval in accordance with local regulations. All methods were performed in accordance with the ethical standards outlined in the 1964 Declaration of Helsinki and its later amendments. Informed consent was obtained from all participants.

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He, S., Yang, F., Lu, C. et al. Sex-specific differences in patients with psoriatic arthritis:a nationwide study from the Chinese Registry of Psoriatic Arthritis (CREPAR IV). Clin Rheumatol 43, 1063–1071 (2024). https://doi.org/10.1007/s10067-023-06859-3

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