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Systemic lupus erythematous readmissions have reduced: a 9-year longitudinal study of the nationwide readmission database

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Abstract

Background

Longitudinal data on the trends in systemic lupus erythematous (SLE) readmissions are limited. We aimed to study trends in 30-day readmissions of patients admitted for SLE flares and all SLE hospitalizations in the USA from 2010 to 2018.

Materials and methods

Data were obtained from the nationwide readmission database (NRD). We performed a retrospective 9-year longitudinal trend analysis using the 2010–2018 NRD databases. We searched for index hospitalizations of adult patients diagnosed with SLE using the International Classification of Diseases (ICD) codes. Elective and traumatic readmissions were excluded from the study. Multivariable logistic and linear regression analyses were used to calculate the adjusted p value trend for categorical and continuous outcomes, respectively.

Results

The 30-day readmissions following index admissions of all SLE patients and for SLE flares decreased from 15.6% in 2010 to 13.3% in 2018 (adjusted p trend < 0.0001), and 20.3% in 2010 to 17.6% in 2018 (adjusted p trend = 0.009) respectively. Following SLE-flare admissions, hospital length of stay (LOS) decreased from 6.7 to 6 days (adjusted p trend = 0.045), while the proportion with a Charlson comorbidity index (CCI) score ≥ 3 increased from 42.2 to 54.4% (adjusted p trend < 0.0001) during the study period. SLE and its organ involvement, sepsis, and infections were common reasons for 30-day readmissions.

Conclusion

About 1 in 5 SLE-flare admissions resulted in a 30-day readmission. The 30-day readmissions following index hospitalization for SLE flares and all SLE hospitalizations have decreased in the last decade. Although the readmission LOS was reduced, the CCI score increased over time.

Key Points

• The 30-day readmissions following index hospitalization for SLE flares and all SLE hospitalizations have reduced in the last decade although the CCI score increased over time.

• SLE, its organ involvement, and infections are common reasons for readmission.

• Infection control strategies, optimal management of SLE and its complications, and emphasis on an ideal transition of care are essential in reducing SLE readmissions.

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Authors and Affiliations

  1. Department of Internal Medicine, Piedmont Athens Regional, Athens, GA, USA

    Osahon Idolor

  2. Division of Rheumatology, Loma Linda University Health, Loma Linda, CA, USA

    Ehizogie Edigin & Vaneet Kaur Sandhu

  3. College of Medicine, University of Benin, Benin, Nigeria

    Precious Obehi Eseaton, Nelson Onyekachukwu Okobia & John Emeke Eboma

  4. Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA

    Amy Trang

  5. Department of Internal Medicine, Central Michigan University, Mount Pleasant, MI, USA

    Asim Kichloo

  6. Department of Internal Medicine, John H. Stroger Hospital of Cook County, Chicago, IL, USA

    Hafeez Shaka

  7. Department of Internal Medicine, Hurley Medical Center, Flint, MI, USA

    Efosa Martins Bazuaye

  8. Department of Internal Medicine, Our Lady of Apostles Hospital, Akwanga, Nigeria

    Fidelis Uwumiro

  9. Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA

    Augustine Manadan

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  1. Osahon Idolor
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Correspondence to Osahon Idolor.

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Idolor, O., Edigin, E., Eseaton, P.O. et al. Systemic lupus erythematous readmissions have reduced: a 9-year longitudinal study of the nationwide readmission database. Clin Rheumatol 42, 377–383 (2023). https://doi.org/10.1007/s10067-022-06476-6

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  • DOI: https://doi.org/10.1007/s10067-022-06476-6

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