Abstract
The aim of this study was to determine the prevalence of metabolic syndrome (MetS) in Iranian patients with systemic lupus erythematosus (SLE) and its determinants. In a cross-sectional study, 98 patients with SLE and 95 controls were enrolled. Prevalence of MetS was determined based on American Heart Association and National Heart, Lung, and Blood Institute (AHA/NHLBI) and 2009 harmonizing criteria. In addition, demographic features and lupus characteristics such as disease duration, pharmacological treatment, laboratory data, SLE disease activity index (SLEDAI), and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage index (SDI) were recorded. The predictors of MetS were obtained by backward stepwise regression analysis. Using AHA/NHLBI, MetS was observed in 35 (35.7%) patients and 28 (29.8%) controls (P = 0.4). Using harmonizing criteria, MetS was observed in 37 (37.7%) patients and 33 (35.1%) controls (P = 0.7). There was no difference in frequency distribution of MetS components between the patients and the controls. In multivariate regression analysis, low C3, blood urea nitrogen (BUN), and body mass index were independent determinants of MetS in lupus patients. BUN, low C3, and body mass index were the major determinants of MetS in lupus patients.
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O'Sullivan M, Bruce IN, Symmons DP (2016) Cardiovascular risk and its modification in patients with connective tissue diseases. Best Pract Res Clin Rheumatol 30(1):81–94. https://doi.org/10.1016/j.berh.2016.03.003
Bruce IN, Urowitz MB, Gladman DD, Ibanez D, Steiner G (2003) Risk factors for coronary heart disease in women with systemic lupus erythematosus: the Toronto risk factor study. Arthritis Rheum 48(11):3159–3167. https://doi.org/10.1002/art.11296
Bessant R, Hingorani A, Patel L, MacGregor A, Isenberg DA, Rahman A (2004) Risk of coronary heart disease and stroke in a large British cohort of patients with systemic lupus erythematosus. Rheumatology (Oxford) 43(7):924–929. https://doi.org/10.1093/rheumatology/keh213
Bruce IN (2005) 'Not only...But also': factors that contribute to accelerated atherosclerosis and premature coronary heart disease in systemic lupus erythematosus. Rheumatology (Oxford) 44(12):1492–1502. https://doi.org/10.1093/rheumatology/kei142
Esdaile JM, Abrahamowicz M, Grodzicky T, Li Y, Panaritis C, du Berger R, Cote R, Grover SA, Fortin PR, Clarke AE, Senecal JL (2001) Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus. Arthritis Rheum 44(10):2331–2337. https://doi.org/10.1002/1529-0131(200110)44:10%3C2331::AID-ART395%3E3.0.CO;2-I
McNeill AM, Rosamond WD, Girman CJ, Golden SH, Schmidt MI, East HE, Ballantyne CM, Heiss G (2005) The metabolic syndrome and 11-year risk of incident cardiovascular disease in the atherosclerosis risk in communities study. Diabetes Care 28(2):385–390. https://doi.org/10.2337/diacare.28.2.385
Malik S, Wong ND, Franklin SS, Kamath TV, L'Italien GJ, Pio JR, Williams GR (2004) Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation 110(10):1245–1250. https://doi.org/10.1161/01.cir.0000140677.20606.0e
Gami AS, Witt BJ, Howard DE, Erwin PJ, Gami LA, Somers VK, Montori VM (2007) Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol 49(4):403–414. https://doi.org/10.1016/j.jacc.2006.09.032
Parker B, Bruce IN (2010) The metabolic syndrome in systemic lupus erythematosus. Rheum Dis Clin N Am 36:81–97, viii. https://doi.org/10.1016/j.rdc.2009.12.004
Parker B, Bruce I (2013) SLE and metabolic syndrome. Lupus 22(12):1259–1266. https://doi.org/10.1177/0961203313502570
Azimi-Nezhad M, Herbeth B, Siest G, Dade S, Ndiaye NC, Esmaily H, Hosseini SJ, Ghayour-Mobarhan M, Visvikis-Siest S (2012) High prevalence of metabolic syndrome in Iran in comparison with France: what are the components that explain this? Metab Syndr Relat Disord 10(3):181–188. https://doi.org/10.1089/met.2011.0097
Noshad S, Abbasi M, Etemad K, Meysamie A, Afarideh M, Khajeh E, Asgari F, Mousavizadeh M, Rafei A, Neishaboury M, Ghajar A, Nakhjavani M, Koohpayehzadeh J, Esteghamati A (2017) Prevalence of metabolic syndrome in Iran: a 2011 update. J Diabetes 9(5):518–525. https://doi.org/10.1111/1753-0407.12438
Tabatabaie AH, Shafiekhani M, Nasihatkon AA, Rastani IH, Tabatabaie M, Borzoo AR, Hojat F (2015) Prevalence of metabolic syndrome in adult population in shiraz, southern Iran. Diabetes Metab Syndr 9(3):153–156. https://doi.org/10.1016/j.dsx.2015.04.012
Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725. https://doi.org/10.1002/1529-0131(199709)40:9<1725::AID-ART29>3.0.CO;2-Y
Gladman DD, Ibanez D, Urowitz MB (2002) Systemic lupus erythematosus disease activity index 2000. J Rheumatol 29(2):288–291
Gladman D, Ginzler E, Goldsmith C, Fortin P, Liang M, Urowitz M, Bacon P, Bombardieri S, Hanly J, Hay E, Isenberg D, Jones J, Kalunian K, Maddison P, Nived O, Petri M, Richter M, Sanchez-Guerrero J, Snaith M, Sturfelt G, Symmons D, Zoma A (1996) The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus. Arthritis Rheum 39(3):363–369. https://doi.org/10.1002/art.1780390303
Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F (2005) Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Circulation 112(17):2735–2752. https://doi.org/10.1161/circulationaha.105.169404
Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120(16):1640–1645. https://doi.org/10.1161/circulationaha.109.192644
Parker B, Ahmad Y, Shelmerdine J, Edlin H, Yates AP, Teh LS, Bruce IN (2011) An analysis of the metabolic syndrome phenotype in systemic lupus erythematosus. Lupus 20(14):1459–1465. https://doi.org/10.1177/0961203311416695
Sabio JM, Zamora-Pasadas M, Jimenez-Jaimez J, Albadalejo F, Vargas-Hitos J, Rodriguez del Aguila MD, Hidalgo-Tenorio C, Gonzalez-Gay MA, Jimenez-Alonso J (2008) Metabolic syndrome in patients with systemic lupus erythematosus from Southern Spain. Lupus 17(9):849–859. https://doi.org/10.1177/0961203308093554
El Magadmi M, Ahmad Y, Turkie W, Yates AP, Sheikh N, Bernstein RM, Durrington PN, Laing I, Bruce IN (2006) Hyperinsulinemia, insulin resistance, and circulating oxidized low density lipoprotein in women with systemic lupus erythematosus. J Rheumatol 33(1):50–56
Vadacca M, Margiotta D, Rigon A, Cacciapaglia F, Coppolino G, Amoroso A, Afeltra A (2009) Adipokines and systemic lupus erythematosus: relationship with metabolic syndrome and cardiovascular disease risk factors. J Rheumatol 36(2):295–297. https://doi.org/10.3899/jrheum.080503
Azevedo GD, Gadelha RG, Vilar MJ (2007) Metabolic syndrome in systemic lupus erythematosus: lower prevalence in Brazil than in the USA. Ann Rheum Dis 66(11):1542. https://doi.org/10.1136/ard.2007.074583
Bellomio V, Spindler A, Lucero E, Berman A, Sueldo R, Berman H, Santana M, Molina MJ, Gongora V, Cassano G, Paira S, Saurit V, Retamozo S, Alvarellos A, Caerio F, Alba P, Gotero M, Velozo EJ, Ceballos F, Soriano E, Catoggio L, Garcia MA, Eimon A, Aguero S (2009) Metabolic syndrome in Argentinean patients with systemic lupus erythematosus. Lupus 18(11):1019–1025. https://doi.org/10.1177/0961203309105876
Negron AM, Molina MJ, Mayor AM, Rodriguez VE, Vila LM (2008) Factors associated with metabolic syndrome in patients with systemic lupus erythematosus from Puerto Rico. Lupus 17(4):348–354. https://doi.org/10.1177/0961203307086645
Chung CP, Avalos I, Oeser A, Gebretsadik T, Shintani A, Raggi P, Stein CM (2007) High prevalence of the metabolic syndrome in patients with systemic lupus erythematosus: association with disease characteristics and cardiovascular risk factors. Ann Rheum Dis 66(2):208–214. https://doi.org/10.1136/ard.2006.054973
Zabetian A, Hadaegh F, Azizi F (2007) Prevalence of metabolic syndrome in Iranian adult population, concordance between the IDF with the ATPIII and the WHO definitions. Diabetes Res Clin Pract 77(2):251–257. https://doi.org/10.1016/j.diabres.2006.12.001
Hwang LC, Bai CH, Chen CJ (2006) Prevalence of obesity and metabolic syndrome in Taiwan. J Formos Med Assoc 105(8):626–635. https://doi.org/10.1016/s0929-6646(09)60161-3
Jeppesen J, Hansen TW, Rasmussen S, Ibsen H, Torp-Pedersen C, Madsbad S (2007) Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease: a population-based study. J Am Coll Cardiol 49(21):2112–2119. https://doi.org/10.1016/j.jacc.2007.01.088
Cameron AJ, Magliano DJ, Zimmet PZ, Welborn T, Shaw JE (2007) The metabolic syndrome in Australia: prevalence using four definitions. Diabetes Res Clin Pract 77(3):471–478. https://doi.org/10.1016/j.diabres.2007.02.002
Ford ES, Giles WH (2003) A comparison of the prevalence of the metabolic syndrome using two proposed definitions. Diabetes Care 26(3):575–581. https://doi.org/10.2337/diacare.26.3.575
Aguilar-Salinas CA, Rojas R, Gomez-Perez FJ, Valles V, Rios-Torres JM, Franco A, Olaiz G, Rull JA, Sepulveda J (2004) High prevalence of metabolic syndrome in Mexico. Arch Med Res 35(1):76–81. https://doi.org/10.1016/j.arcmed.2003.06.006
Hatef-Fard MR, Khodabandeh M, Sahebari M, Ghayour-Mobarhan M, Rezaieyazdi Z (2016) Metabolic syndrome in lupus patients in northeast of Iran, and their lifestyle habits. Caspian J Intern Med 7(3):195–200
Sabio JM, Vargas-Hitos J, Zamora-Pasadas M, Mediavilla JD, Navarrete N, Ramirez A, Hidalgo-Tenorio C, Jaimez L, Martin J, Jimenez-Alonso J (2009) Metabolic syndrome is associated with increased arterial stiffness and biomarkers of subclinical atherosclerosis in patients with systemic lupus erythematosus. J Rheumatol 36(10):2204–2211. https://doi.org/10.3899/jrheum.081253
Liu SY, Han LS, Guo JY, Zheng ZH, Li H, Zhang L, Zhang X, He YJ, Gao GM, Liu ZS, Zeng XF (2013) Metabolic syndrome in Chinese patients with systemic lupus erythematosus: no association with plasma cortisol level. Lupus 22(5):519–526. https://doi.org/10.1177/0961203313478301
Bultink IE, Turkstra F, Diamant M, Dijkmans BA, Voskuyl AE (2008) Prevalence of and risk factors for the metabolic syndrome in women with systemic lupus erythematosus. Clin Exp Rheumatol 26(1):32–38
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The authors would like to express their sincere thanks to Professor Roya Kelishadi who peer reviewed our article.
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Fatemi, A., Ghanbarian, A., Sayedbonakdar, Z. et al. Metabolic syndrome in Iranian patients with systemic lupus erythematosus and its determinants. Clin Rheumatol 37, 1521–1528 (2018). https://doi.org/10.1007/s10067-017-3970-5
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DOI: https://doi.org/10.1007/s10067-017-3970-5