Abstract
We aimed to analyse the nailfold capillaryscopy findings morphologically and examine their relationship with disease activity and demographic characteristics in patients with rheumatoid arthritis. In accordance with the 2010 ACR/EULAR classification criteria, 201 patients diagnosed with Romatoiad artrit (RA) and 50 healthy controls were included. We analysed capillaroscopic abnormalities such asmegacapillaries, haemorrhages, ramifications and avascular areas in patients affected with rheumatoid arthritis. The findings in our study are as follows: in 45.77% of the RA patients, there were nonspecific capillaryscopy findings. When compared to control group, the incidence of tortuosity, dilated capillary and bushy capillary was higher in RA patients (p values, respectively, 0.110, 0.330, 0.440 and 0.516). In RA patients with Raynaud’s phenomenon, the incidence of nonspecific capillaryscopy findings was higher. While there is a weak relationship between tortuosity and the duration of disease, no significant relation was detected between capillaryscopy findings and parameters such as RF, anti-CCP positivity and disease activity score (DAS28). When compared to controls, we have detected that RA patients have more nonspecific capillaryscopic findings. We could not find a relationship between nonspecific capillaryscopic findings and RA’a clinical findings and laboratory parameters. There is a need for a long-term wider-scale follow-up study to investigate whether there is a capillaryscopic pattern that can be correlated with RA’s clinical findings.
Similar content being viewed by others
References
Lambova SN, Müller-Ladner U (2013) Capillaroscopic pattern in systemic lupus erythematosus and undifferentiated connective tissue disease: what we still have to learn? Rheumatol Int 33(3):689–695
LeRoy EC, Medsger TA (2001) Criteria for the classification of early systemic sclerosis. J Rheumatol 28:1573–1576
Van den Hoogen F, Khanna D, Fransen J et al (2013) 2013 classification criteria for systemic sclerosis: an american college of rheumatology/European league against rheumatism collaborative initiative. Arthritis & Rheumatism 65(11):2737–2747
Cutolo M, Pizzorni C, Secchi ME, Sulli A (2008) Capillaroscopy. Best Pract Res Clin Rheumatol 22(6):1093–1108
Lambova SN, Hermann W, Müller-Ladner U (2012) Comparison of qualitative and quantitative analysis of capillaroscopic findings in patients with rheumatic diseases. Rheumatol Int 32:3729–3735
Graceffa D, Amorosi B, Maiani E, Bonifati C, Chimenti MS, Perricone R, Di Carlo A (2013) Capillaroscopy in psoriatic and rheumatoid arthritis: a useful tool for differential diagnosis. Arthritis 2013:957480
Moreli S, Ferri C, Polettini E, Bellini C, Gualdi GF, Pittoni V, Valesini G, Santucci A (1995) Plasma endothelin-1 levels, pulmonary hypertension, and lung fibrosis in patients with systemic sclerosis. Am J Med 99:255–260
Kuryliszyn-Moskal A, Klimiuk PA, Sierakowski S (2005) Soluble adhesion molecules (sVCAM-1, sE-selectin), vascular endothelial growth factor (VEGF) and endothelin-1 in patients with systemic sclerosis: relationship to organ systemic involvement. Clin Rheumatol 24:111–116
Ballara S, Taylor PC, Reusch P, Marme D, Maini RN, Paleolog E (2001) Serum vascular endothelial growth factor (VEGF) and soluble VEGF receptor in inflammatory arthritis. Arthritis Rheum 44:2055–2064
Kuryliszyn-Moskal A, Klimiuk PA, Sierakowski S, Ciolkiewicz M (2006) A study on vascular endothelial growth factor and endothelin-1 in patients with extra-articular involvement of rheumatoid arthritis. Clin Rheumatol 25:314–319
Cutolo M, Pizzorni C, Sulli A (2004) Nailfold video-capillaroscopy in systemic sclerosis. Z Rheumatol 63:457–462
Hachulla E, Perez-Cousin M, Flipo RM et al (1994) Increased capillary permeability in systemic rheumatoid vasculitis: detection by dynamic fluorescence nailfold videomicroscopy. J Rheumatol 21(7):1197–1202
Corominas H, Ortiz-Santamaria V, Castellví I, Moreno M, Morlà R, Clavaguera T, Erra A, Martinez-Pardo S, Ordóñez S, Santo P, Reyner P, José González M, Codina O, Saul Gelman M, Juanola-Roura X, Olivé A, Torrente-Segarra V (2016) Capi CAT group. Nailfold capillaroscopic findings in primary Sjögren’s syndrome with and without Raynaud’s phenomenon and/or positive anti-SSA/Ro and anti-SSB/la antibodies. Rheumatol Int 36:365–369
Meyer MF, Schmidt O, Hellmich B, Schatz H, Klein HH, Braun J (2007) Microvascular dysfunction in rheumatoid arthritis assessed by laser Doppler anemometry: relationship to soluble adhesion molecules and extraarticular manifestations. Rheumatol Int 28(2):145–152
Klyscz T, Bogenschutz O, Junger M, Rassner G (1996) Microangiopathic changes and functional disorders of nail fold capillaries in dermatomyositis. Hautarzt 47:289–293
Ingegnoli F, Zeni S, Meani L et al (2005) Evaluation of nailfold videocapillaroscopic abnormalities in patients with systemic lupus erythematosus. J Clin Rheumatol 11:295–298
Riccieri V, Spadaro A, Ceccarelli F et al (2005) Nailfold capillaroscopy changes in systemic lupus erythematosus: correlations with disease activity and autoantibody profile. Lupus 14:521–525
Nagy Y, Czirjak L (2004) Nailfold digital capillaroscopy in 447 patients with connective tissue disease and Raynaud’s disease. J Eur Acad Dermatol Venereol 18:62–68
Altomonte L, Zoli A, Galossi A, Mirone L, Tulli A, Martone FR, Morini P, Laraia P, Magarò M (1995) Microvascular capillaroscopic abnormalities in rheumatoid arthritis patients. Clin Exp Rheumatol 13(1):83–86
Caspary L, Schmees C, Schoetensack I, Hartung K, Stannat S, Deicher H et al (1991) Alterations of the nailfold capillary morphology associated with Raynaud phenomenon in patients with systemic lupus erythematosus. J Rheumatol 18:559–566
Lekakis J, Mavrikakis M, Emmanuel M, Prassopoulos V, Papazoglou S, Papamichael C, Moulopoulou D, Kostamis P, Stamatelopoulos S, Moulopoulos S (1998) Cold-induced coronary Raynaud’s phenomenon in patients with systemic sclerosis. Clin Exp Rheumatol 16(2):135–140
Mathews JL, Ward JR, Samuelson CO, Knibbe WP (1983) Spontaneous nasal septal perforation in patients with rheumatoid arthritis. Clin Rheumatol 2(1):13–18
Mourao AF, Amaral M, Caetano-Lopes J, Isenberg D (2009) An analysis of joint replacement in patients with systemic lupus erythematosus. Lupus 18(14):1298–1302
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
The study was approved by our unıversıty medicine faculty local ethics committee.
Disclosures
None.
Rights and permissions
About this article
Cite this article
Sag, S., Sag, M.S., Tekeoglu, I. et al. Nailfold videocapillaroscopy results in patients with rheumatoid arthritis. Clin Rheumatol 36, 1969–1974 (2017). https://doi.org/10.1007/s10067-017-3696-4
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-017-3696-4