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Coexistence of arrhythmogenic right ventricular cardiomyopathy and chronic myocarditis in children

  • Original Research
  • Published:
Annals of Diagnostic Paediatric Pathology

Abstract

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a cardiomyopathy described in adults as a risk factor in sudden unexpected cardiac death. The disease is of unknown etiology and is characterized by progressive fatty or fibrofatty replacement of the subendocardial layer of the heart muscle, predominantly of the right ventricle. The disease is not associated with primary pulmonary disease or mitral insufficiency. The aim of the present paper is to show that ARVC in children coexists with chronic myocarditis, as was shown with the aid of immunocytochemical staining for markers for T-lymphocytes (CD3, CD4, CD8) B lymphocytes (CD22) and macrophages (CD68), and for adhesion molecules (ICAM-1, VCAM, ELAM) and an endothelial marker (CD31/PECAM-1). Out of 55 endomyocardial biopsy specimens in children with a clinical diagnosis of dilated cardiomyopathy, myocarditis or arrhythmias, ARVD was recognized histologically in 12 patients (21.8%). Nine of these patients had shown immunocytochemical equivalents of persistent myocarditis.

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Authors and Affiliations

  1. Department of Pathology, The Children’s Memorial Health Institute, Aleja Dzieci Polskich 20, PL-04736, Warsaw, Poland

    B. Woźniewicz, E. Czarnowska & J. Cielecka-Kuszyk

  2. Department of Cardiology, The Children’s Memorial Health Institute, Warsaw, Poland

    K. Kubicka & L. Ziółkowska

  3. Central Polish Railway Hospital, Warsaw, Poland

    T. Zaleska

Authors
  1. B. Woźniewicz
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  2. E. Czarnowska
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  3. K. Kubicka
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  4. L. Ziółkowska
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  5. J. Cielecka-Kuszyk
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  6. T. Zaleska
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Correspondence to B. Woźniewicz.

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Woźniewicz, B., Czarnowska, E., Kubicka, K. et al. Coexistence of arrhythmogenic right ventricular cardiomyopathy and chronic myocarditis in children. Ann Diagn Paed Pathol 2, 13–17 (1998). https://doi.org/10.1007/s100570050003

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  • DOI: https://doi.org/10.1007/s100570050003

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