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Implantation study of a tissue-engineered self-expanding aortic stent graft (bio stent graft) in a beagle model

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Abstract

The use of stent grafts for endovascular aortic repair has become an important treatment option for aortic aneurysms requiring surgery. This treatment has achieved excellent outcomes; however, problems like type 1 endoleaks and stent graft migration remain. Bio stent grafts (BSGs), which are self-expanding stents covered with connective tissue, were previously developed using “in-body tissue architecture” technology. We assessed their early adaptation to the aorta after transcatheter implantation in a beagle model. BSGs were prepared by subcutaneous embedding of acryl rods mounted with self-expanding nitinol stents in three beagles for 4 weeks (n = 3/dog). The BSGs were implanted as allografts into infrarenal abdominal aortas via the femoral artery of three other beagles. After 1 month of implantation, aortography revealed no stenosis or aneurysmal changes. The luminal surface of the BSGs was completely covered with neointimal tissue, including endothelialization, without any thrombus formation. The cover tissue could fuse the luminal surface of the native aorta with tight conjunctions even at both ends of the stents, resulting in complete impregnation of the strut into the reconstructed vascular wall, which is expected to prevent endoleaks and migration in clinical applications.

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Acknowledgments

The authors thank Mr. Yasuhiro Hoshino (Piolax) for his participation in this study.

Conflict of interest

None declared.

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Authors and Affiliations

  1. Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, 565-8565, Japan

    Hidetake Kawajiri, Takeshi Mizuno, Takeshi Moriwaki, Ryosuke Iwai, Masashi Yamanami & Yasuhide Nakayama

  2. Department of Cardiovascular Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Hidetake Kawajiri, Masashi Yamanami, Keiichi Kanda & Hitoshi Yaku

  3. Department of Pathology, National Cerebral and Cardiovascular Center, Suita, Japan

    Hatsue Ishibashi-Ueda

Authors
  1. Hidetake Kawajiri
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  2. Takeshi Mizuno
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  3. Takeshi Moriwaki
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  4. Ryosuke Iwai
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  5. Hatsue Ishibashi-Ueda
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  6. Masashi Yamanami
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  7. Keiichi Kanda
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  8. Hitoshi Yaku
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  9. Yasuhide Nakayama
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Corresponding authors

Correspondence to Hidetake Kawajiri or Yasuhide Nakayama.

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Kawajiri, H., Mizuno, T., Moriwaki, T. et al. Implantation study of a tissue-engineered self-expanding aortic stent graft (bio stent graft) in a beagle model. J Artif Organs 18, 48–54 (2015). https://doi.org/10.1007/s10047-014-0796-7

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  • DOI: https://doi.org/10.1007/s10047-014-0796-7

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