Skip to main content
SpringerLink
Log in

Concept of left atrial pressure estimation using its pulsatile amplitude in the helical flow total artificial heart

  • Original Article
  • Artificial Heart (Basic)
  • Published:
Journal of Artificial Organs Aims and scope Submit manuscript

Abstract

The total artificial heart (TAH) requires physiological control to respond to the metabolic demand of the body. To date, 1/R control is a single physiological control method that can control venous pressure. To realize an implantable 1/R control system, we are developing a new pressure measuring method using absolute pressure sensor. To find a method for absolute pressure sensor, which went well without calibration, concept of left atrial pressure (LAP) estimation using its pulsatile amplitude was proposed. Its possibility was investigated with two long-term survived goats whose hearts were replaced with the helical flow TAHs. In manual control condition, there existed a positive relation between mean LAP (mLAP) and normalized pulsatile amplitude (NPA). Percent systole revealed not to affect the relationship between mLAP and NPA. Dispersion was observed between different pulse rates. As for cardiac output difference (QLD) that is the difference of flow rate between systolic and diastolic phases, similar results were obtained except in low QLDs. In the 1/R control condition, relatively high correlation between mLAP and NPA could be obtained. In estimation of mLAP using the correlating function of individual goat, fairly good correlation was obtained between measured mLAP and estimated mLAP. Despite that further studies are necessary, it was demonstrated that the concept of the LAP estimation could be possible.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Hiller KW, Seidel W, Kolff WJA. Servo mechanism to drive an artificial heart inside the chest. ASAIO Trans. 1962;8:125–30.

    Article  CAS  Google Scholar 

  2. Auhero TX, Magovern JA, Rosenberg G, Pal WE, Donachy JH, Pierce WS. Long-term survival with a pneumatic artificial heart. ASAIO Trans. 1987;33:157–61.

    Google Scholar 

  3. Vasku J. Perspectives of total artificial heart research as a valuable modelling system for general physiology and pathophysiology. In: Akutsu T, Koyanagi H, editors. Heart replacement-artif heart 4. Tokyo: Springer; 1992. p. 161–71.

    Google Scholar 

  4. Hennig E, Grosse-Siestrup C, Krautzberger W, Kless H, Bucherl ES. The relationship of cardiac output and venous pressure in long surviving calves with total artificial heart. ASAIO Trans. 1978;24:616–23.

    CAS  Google Scholar 

  5. Takatani S, Harasaki H, Koike S, Yada I, Yozu R, Fujimoto L, Murabayashi S, Jacobs G, Kiraly R, Nosial. Optimum control mode for a total artificial heart. ASAIO Trans. 1982;28:148–53.

    CAS  Google Scholar 

  6. Pierce WS, Landis D, O’bannon W, Pierce WS, Landis D, O’Bannon W, Donachy JH, White W, Phillips W, Brighton JA, et al. Automatic control of artificial heart. ASAIO Trans. 1976;22:347–56.

    CAS  Google Scholar 

  7. Snyder AJ, Rosenberg G, Reibson J, Donachy JH, Prophet GN, Arenas J, Daily B, Mcgary S, Kawaguchi O, Quinn R, Pierce WS. An electrically powered total artificial heart-Over one year survival in the calf. ASAIO J. 1992;38:M707–12.

    Article  CAS  PubMed  Google Scholar 

  8. Abe Y, Chinzei T, Mabuchi K, Snyder AJ, Isoyama T, Imanishi K, Yonezawa T, Matsuura H, Kouno A, Ono T, Atsumi K, Fujimasa F, Imachi K. Physiological control of a total artificial heart: conductance- and arterial pressure-based control. J Appl Physiol. 1998;84:868–76.

    CAS  PubMed  Google Scholar 

  9. Abe Y, Chinzei T, Mabuchi K, Isoyama T, Baba K, Matsuura H, Kouno A, Ono T, Mochizuki S, Sun YP, Imanishi K, Atsumi K, Fujimasa I, Imachi K. Over 500 days survival of a total artificial heart goat with 1/R control. In: Akutsu T, Koyanagi H, editors. Heart replacement: artificial heart 6. Tokyo: Springer; 1998. p. 34–40.

    Chapter  Google Scholar 

  10. Abe Y, Ishii K, Isoyama T, Saito I, Inoue Y, Sato M, Hara S, Hosoda K, Ariyoshi K, Nakagawa H, Ono T, Fukazawa K, Ishihara K, Imachi K. The helical flow total artificial heart: implantation in goats. Conf Proc IEEE Eng Med Biol Soc. 2013;2013:2720–3.

  11. Abe Y, Ishii K, Isoyama T, Saito I, Inoue Y, Ono T, Nakagawa H, Nakano E, Fukazawa K, Ishihara K, Fukunaga K, Ono M, Imachi K. The helical flow pump with a hydrodynamic levitation impeller. J Artif Organs. 2012;15:331–40.

    Article  PubMed  Google Scholar 

  12. Yoshizawa M, Sato T, Tanaka A, Abe K, Takeda H, Yambe T, Nitta S, Nosé Y. Sensorless estimation of pressure head and flow of a continuous flow artificial heart based on input power and rotational speed. ASAIO J. 2002;48:443–8.

    Article  PubMed  Google Scholar 

  13. Shi W, Saito I, Isoyama T, Nakagawa H, Inoue Y, Ono T, Kouno A, Imachi K, Abe Y. Automatic calibration of the inlet pressure sensor for the implantable continuous-flow ventricular assist device. J Artif Organs. 2011;14:81–8.

    Article  PubMed  Google Scholar 

  14. Saito I, Chinzei T, Isoyama T, Miura H, Kouno A, Ono T, Nakagawa H, Yamaguchi-Sekino S, Shi W, Inoue Y, Kishi A, Abe Y. Implementation of the natural heartbeat synchronize control for the undulation pump ventricular assist device using the inflow pressure. IFMBE Proc. 2008;19:62–5.

    Article  Google Scholar 

Download references

Acknowledgments

The study was supported in part by the JSPS KAKENHI (22249053) and (22240054).

Conflict of interest

There is no conflict of interest needed to disclose in this study.

Author information

Authors and Affiliations

  1. Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Sheng-Yuan Wu, Itsuro Saito, Takashi Isoyama, Masami Sato, Shintaro Hara, Xin-Yang Li, Terumi Yurimoto, Haruka Murakami, Toshiya Ono & Yusuke Abe

  2. Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan

    Yusuke Inoue

  3. Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan

    Yukino Kawase

Authors
  1. Sheng-Yuan Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Itsuro Saito
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takashi Isoyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yusuke Inoue
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Masami Sato
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shintaro Hara
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Xin-Yang Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Terumi Yurimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Haruka Murakami
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Yukino Kawase
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Toshiya Ono
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Yusuke Abe
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Itsuro Saito or Yusuke Abe.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wu, SY., Saito, I., Isoyama, T. et al. Concept of left atrial pressure estimation using its pulsatile amplitude in the helical flow total artificial heart. J Artif Organs 17, 301–307 (2014). https://doi.org/10.1007/s10047-014-0788-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10047-014-0788-7

Keywords

Search

Navigation