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Germinoma with an extensive rhabdoid cell component centered at the corpus callosum

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Abstract

Intracranial germinomas comprise 0.5–2.0 % of all central nervous system (CNS) tumors and 50–60 % of CNS germ cell tumors. They most frequently originate in the pineal gland and the suprasellar region. The corpus callosum is an extremely uncommon location for germinoma formation. Herein, we report about a 20-year-old man with a germinoma centered at the corpus callosum and that extended to both cerebral hemispheres. In addition to its location, this case is unique in that the amount of tumor cells with rhabdoid morphology exceeded that of tumor cells with typical morphology. The rhabdoid cell component showed an immunophenotype compatible with germinoma. While the presence of rhabdoid cells is generally regarded as a sign of aggressive behavior, the patient has been doing well for at least 4 years since undergoing radiation therapy and chemotherapy. The cellular composition of germinoma might not critically affect prognosis with adequate treatment.

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References

  1. Gao Y, Jiang J, Liu Q (2014) Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience. Int J Clin Exp Pathol 7(10):6965–6972

    PubMed  PubMed Central  Google Scholar 

  2. Jennings MT, Gelman R, Hochberg F (1985) Intracranial germ-cell tumors: natural history and pathogenesis. J Neurosurg 63(2):155–167. doi:10.3171/jns.1985.63.2.0155

    Article  CAS  PubMed  Google Scholar 

  3. Matsutani M, Sano K, Takakura K, Fujimaki T, Nakamura O, Funata N, Seto T (1997) Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases. J Neurosurg 86(3):446–455. doi:10.3171/jns.1997.86.3.0446

    Article  CAS  PubMed  Google Scholar 

  4. Tso WW, Yung AW, Lau HY, Chan GC (2014) Basal ganglia germinoma: MRI classification correlates well with neurological and cognitive outcome. J Pediatr Hematol Oncol 36(7):e443–e447. doi:10.1097/MPH.0000000000000014

    Article  PubMed  Google Scholar 

  5. Sartori S, Laverda AM, Calderone M, Carollo C, Viscardi E, Faggin R, Perilongo G (2007) Germinoma with synchronous involvement of midline and off-midline structures associated with progressive hemiparesis and hemiatrophy in a young adult. Childs Nerv Syst 23(11):1341–1345. doi:10.1007/s00381-007-0390-x

    Article  CAS  PubMed  Google Scholar 

  6. Utsuki S, Oka H, Tanizaki Y, Kondo K, Fujii K (2005) Radiological features of germinoma arising from atypical locations. Neurol Med Chir (Tokyo) 45(5):268–271

    Article  Google Scholar 

  7. Kawai N, Miyake K, Nishiyama Y, Yamamoto Y, Miki A, Haba R, Imai T, Tamiya T, Nagao S (2008) Targeting optimal biopsy location in basal ganglia germinoma using (11)C-methionine positron emission tomography. Surg Neurol 70(4):408–413. doi:10.1016/j.surneu.2007.04.010 (discussion 413)

    Article  PubMed  Google Scholar 

  8. Fujiwara K, Uenohara H, Suzuki H, Sakurai Y (2002) Intracranial germinoma with syncytiotrophoblastic giant cells in the cerebellopontine angle–case report. Neurol Med Chir (Tokyo) 42(3):132–136

    Article  Google Scholar 

  9. Yen PS, Chou AS, Chen CJ, Jung SM, Chuang HL, Scott RM (2003) Primary medulla oblongata germinoma: a case report and review of the literature. J Neurooncol 62(3):339–342

    Article  PubMed  Google Scholar 

  10. Madhukar M, Maller VG, Choudhary AK, Iantosca MR, Specht CS, Dias MS (2013) Primary intramedullary spinal cord germinoma. J Neurosurg Pediatr 11(5):605–609. doi:10.3171/2013.1.PEDS12402

    Article  PubMed  Google Scholar 

  11. Tamaki N, Lin T, Shirataki K, Hosoda K, Kurata H, Matsumoto S, Ito H (1990) Germ cell tumors of the thalamus and the basal ganglia. Childs Nerv Syst 6(1):3–7

    Article  CAS  PubMed  Google Scholar 

  12. McCarthy BJ, Shibui S, Kayama T, Miyaoka E, Narita Y, Murakami M, Matsuda A, Matsuda T, Sobue T, Palis BE, Dolecek TA, Kruchko C, Engelhard HH, Villano JL (2012) Primary CNS germ cell tumors in Japan and the United States: an analysis of 4 tumor registries. Neuro Oncol 14(9):1194–1200. doi:10.1093/neuonc/nos155

    Article  PubMed  PubMed Central  Google Scholar 

  13. Packer RJ, Cohen BH, Cooney K (2000) Intracranial germ cell tumors. Oncologist 5(4):312–320

    CAS  PubMed  Google Scholar 

  14. So SC, Ho J (1980) Multiple primary germinomas (ectopic pinealoma) of the brain. Neurochirurgia (Stuttg) 23(4):147–150. doi:10.1055/s-2008-1053876

    CAS  Google Scholar 

  15. Liang L, Korogi Y, Sugahara T, Ikushima I, Shigematsu Y, Okuda T, Takahashi M, Kochi M, Ushio Y (2002) MRI of intracranial germ-cell tumours. Neuroradiology 44(5):382–388. doi:10.1007/s00234-001-0752-0

    Article  CAS  PubMed  Google Scholar 

  16. Yonezawa H, Shinsato Y, Obara S, Oyoshi T, Hirano H, Kitajima S, Arita K (2010) Germinoma with syncytiotrophoblastic giant cells arising in the corpus callosum. Neurol Med Chir (Tokyo) 50(7):588–591

    Article  Google Scholar 

  17. Chuan Aaron FS, Dawn CQ, Kenneth CT, Hoe NW, Yen SS, Chee Kian T (2013) Primary human chorionic gonadotropin secreting germinoma of the corpus callosum. Surg Neurol Int 4:137. doi:10.4103/2152-7806.119537

    Article  PubMed  PubMed Central  Google Scholar 

  18. Yang P, Li L, Kuang W, Li B, Zhou B, Yang J, Huang H (2014) Intracranial multiple germ cell tumors: a case report and review of literature. Int J Clin Exp Pathol 7(12):9002–9007

    PubMed  PubMed Central  Google Scholar 

  19. Qu B, Du L, Huang Y, Yu W, Cai B, Xu S, Ma L (2014) Clinical analysis of intracranial germinoma’s craniospinal irradiation using helical tomotherapy. Chin J Cancer Res 26(3):247–254. doi:10.3978/j.issn.1000-9604.2014.05.02

    PubMed  PubMed Central  Google Scholar 

  20. Kodet R, Newton WA Jr, Hamoudi AB, Asmar L (1991) Rhabdomyosarcomas with intermediate-filament inclusions and features of rhabdoid tumors. Light microscopic and immunohistochemical study. Am J Surg Pathol 15(3):257–267

    Article  CAS  PubMed  Google Scholar 

  21. Oshiro Y, Shiratsuchi H, Oda Y, Toyoshima S, Tsuneyoshi M (2000) Rhabdoid features in leiomyosarcoma of soft tissue: with special reference to aggressive behavior. Mod Pathol 13(11):1211–1218. doi:10.1038/modpathol.3880225

    Article  CAS  PubMed  Google Scholar 

  22. Tsuneyoshi M, Daimaru Y, Hashimoto H, Enjoji M (1987) The existence of rhabdoid cells in specified soft tissue sarcomas. Histopathological, ultrastructural and immunohistochemical evidence. Virchows Arch A Pathol Anat Histopathol 411(6):509–514

    Article  CAS  PubMed  Google Scholar 

  23. Gokden N, Nappi O, Swanson PE, Pfeifer JD, Vollmer RT, Wick MR, Humphrey PA (2000) Renal cell carcinoma with rhabdoid features. Am J Surg Pathol 24(10):1329–1338

    Article  CAS  PubMed  Google Scholar 

  24. Ueyama T, Nagai E, Yao T, Tsuneyoshi M (1993) Vimentin-positive gastric carcinomas with rhabdoid features. A clinicopathologic and immunohistochemical study. Am J Surg Pathol 17(8):813–819

    Article  CAS  PubMed  Google Scholar 

  25. Wick MR, Ritter JH, Dehner LP (1995) Malignant rhabdoid tumors: a clinicopathologic review and conceptual discussion. Semin Diagn Pathol 12(3):233–248

    CAS  PubMed  Google Scholar 

  26. Iczkowski KA, Butler SL, Shanks JH, Hossain D, Schall A, Meiers I, Zhou M, Torkko KC, Kim SJ, MacLennan GT (2008) Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. Hum Pathol 39(2):275–281. doi:10.1016/j.humpath.2007.07.002

    Article  CAS  PubMed  Google Scholar 

  27. Mei K, Liu A, Allan RW, Wang P, Lane Z, Abel TW, Wei L, Cheng H, Guo S, Peng Y, Rakheja D, Wang M, Ma J, Rodriguez MM, Li J, Cao D (2009) Diagnostic utility of SALL4 in primary germ cell tumors of the central nervous system: a study of 77 cases. Mod Pathol 22(12):1628–1636. doi:10.1038/modpathol.2009.148

    Article  CAS  PubMed  Google Scholar 

  28. Yang M, Chen X, Wang N, Zhu K, Hu YZ, Zhao Y, Shu Y, Zhao ML, Gu WZ, Tang HF (2014) Primary atypical teratoid/rhabdoid tumor of central nervous system in children: a clinicopathological analysis and review of literature in China. Int J Clin Exp Pathol 7(5):2411–2420

    PubMed  PubMed Central  Google Scholar 

  29. Hollmann TJ, Hornick JL (2011) INI1-deficient tumors: diagnostic features and molecular genetics. Am J Surg Pathol 35(10):e47–e63. doi:10.1097/PAS.0b013e31822b325b

    Article  PubMed  Google Scholar 

  30. Rao Q, Xia QY, Shen Q, Shi SS, Tu P, Shi QL, Zhou XJ (2014) Coexistent loss of INI1 and BRG1 expression in a rhabdoid renal cell carcinoma (RCC): implications for a possible role of SWI/SNF complex in the pathogenesis of RCC. Int J Clin Exp Pathol 7(4):1782–1787

    PubMed  PubMed Central  Google Scholar 

  31. Perrino CM, Hucthagowder V, Evenson M, Kulkarni S, Humphrey PA (2015) Genetic alterations in renal cell carcinoma with rhabdoid differentiation. Hum Pathol 46(1):9–16. doi:10.1016/j.humpath.2014.09.001

    Article  CAS  PubMed  Google Scholar 

  32. Strehl JD, Wachter DL, Fiedler J, Heimerl E, Beckmann MW, Hartmann A, Agaimy A (2015) Pattern of SMARCB1 (INI1) and SMARCA4 (BRG1) in poorly differentiated endometrioid adenocarcinoma of the uterus: analysis of a series with emphasis on a novel SMARCA4-deficient dedifferentiated rhabdoid variant. Ann Diagn Pathol. doi:10.1016/j.anndiagpath.2015.04.001

    PubMed  Google Scholar 

  33. Kanamori M, Kumabe T, Saito R, Yamashita Y, Sonoda Y, Ariga H, Takai Y, Tominaga T (2009) Optimal treatment strategy for intracranial germ cell tumors: a single institution analysis. J Neurosurg Pediatr 4(6):506–514. doi:10.3171/2009.7.PEDS08288

    Article  PubMed  Google Scholar 

  34. Huo L, Wang X, Allen PK, Wang L, Liao Y, Han Z, Shen L, Tu Q, Zhong M, Zhuang Y, Li J, Hong J (2015) Predictors of long-term survival following postoperative radiochemotherapy for pathologically confirmed suprasellar germ cell tumors. Mol Clin Oncol 3(2):430–434. doi:10.3892/mco.2014.461

    PubMed  Google Scholar 

  35. Uematsu Y, Tsuura Y, Miyamoto K, Itakura T, Hayashi S, Komai N (1992) The recurrence of primary intracranial germinomas. Special reference to germinoma with STGC (syncytiotrophoblastic giant cell). J Neurooncol 13(3):247–256

    Article  CAS  PubMed  Google Scholar 

  36. Shibamoto Y, Takahashi M, Sasai K (1997) Prognosis of intracranial germinoma with syncytiotrophoblastic giant cells treated by radiation therapy. Int J Radiat Oncol Biol Phys 37(3):505–510

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Shizuoka Saiseikai General Hospital, 1-1-1 Oshika, Suruga-ku, Shizuoka, 422-8021, Japan

    Shogo Tajima

  2. Department of Pathology, Fujieda Municipal General Hospital, Shizuoka, Japan

    Kenji Koda

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  1. Shogo Tajima
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Correspondence to Shogo Tajima.

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Tajima, S., Koda, K. Germinoma with an extensive rhabdoid cell component centered at the corpus callosum. Med Mol Morphol 50, 52–58 (2017). https://doi.org/10.1007/s00795-015-0111-6

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  • DOI: https://doi.org/10.1007/s00795-015-0111-6

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