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Bone turnover correlates with bone quantity but not bone microarchitecture in chronic hemodialysis

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Abstract

Introduction

In chronic hemodialysis, high-turnover bone disease was associated with decreased bone mineral density (BMD), poor bone quality (chemical and structural), and increased fracture risk. Our aim was to correlate bone turnover markers (BTMs) with bone microarchitecture measured by trabecular bone score (TBS) before and after correction for BMD.

Materials and methods

We measured lumbar spine (LS), femoral neck, and 1/3 radius BMD and LS TBS by dual X-ray absorptiometry in 81 patients on permanent hemodialysis. Bone turnover was assessed using serum parathyroid hormone, osteocalcin, C-terminal crosslaps of type 1 collagen, procollagen 1 N-terminal propeptide (P1NP), and alkaline phosphatase (ALP). No patient had any partial or total parathyroidectomy and no previous or current treatment with anti-osteoporotic drugs.

Results

All BTMs correlated significantly with each other. Univariate regressions showed significant negative correlations between BTMs and BMD (best r = − 0.53, between P1NP and 1/3 radius Z-score) or BTMs and TBS (best r = − 0.27, p < 0.05 between ALP and TBS T-score). TBS correlated significantly with BMD at all three sites (best r = 0.5, between LS BMD and TBS T-score). Multivariate regression showed that TBS, crude or adjusted, correlated with LS BMD. No model retained any of the BTMs as independent variables due to the better prediction of BMD and multicollinearity.

Conclusion

We showed a progressively impaired bone microarchitecture with increasing bone turnover in chronic hemodialysis. However, this correlation is no longer present when controlling for bone mass. This suggests that impaired bone microarchitecture and increased fracture risk are dependent upon factors other than high bone turnover.

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Authors and Affiliations

  1. Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, 34-38 Aviatorilor blvd, 011863, Bucharest, Romania

    Roxana Dusceac, Dan Alexandru Niculescu, Ramona Dobre, Madalina Cristina Sorohan & Catalina Poiana

  2. Research Laboratory, C. I. Parhon National Institute of Endocrinology, 34-38 Aviatorilor blvd, 011863, Bucharest, Romania

    Andra Caragheorgheopol

  3. Diaverum Dialysis Center, 2N Industiilor blvd, 032895, Bucharest, Romania

    Catalin Tacu

  4. Department of Nephrology, Carol Davila University of Medicine and Pharmacy, 13 Vitan-Barzesti rd, 042122, Bucharest, Romania

    Cristiana David

Authors
  1. Roxana Dusceac
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  2. Dan Alexandru Niculescu
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  3. Ramona Dobre
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  4. Madalina Cristina Sorohan
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  5. Andra Caragheorgheopol
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  6. Catalin Tacu
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  7. Cristiana David
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  8. Catalina Poiana
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Contributions

Study design: RDu, DN, and CP; data collection: RDu, RDo, MS, CT, and CD; biochemical assays AC data analysis: RDu and DN; data interpretation: RDu, DN, and CP; drafting manuscript: RDu and DN; revising manuscript content: RDu, DN, RDo, AC, and CP; approving final version of manuscript: RDu, DN, RDo, MS, AC, CT, CD, and CP.

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Correspondence to Dan Alexandru Niculescu.

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Dusceac, R., Niculescu, D.A., Dobre, R. et al. Bone turnover correlates with bone quantity but not bone microarchitecture in chronic hemodialysis. J Bone Miner Metab 38, 597–604 (2020). https://doi.org/10.1007/s00774-020-01094-1

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  • DOI: https://doi.org/10.1007/s00774-020-01094-1

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