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Ameliorative effects of taurine against diabetes: a review

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Abstract

Diets in rats and humans have shown promising results. Taurine improved glucagon activity, promoted glycemic stability, modified glucose levels, successfully addressed hyperglycemia via advanced glycation end-product control, improved insulin secretion and had a beneficial effect on insulin resistance. Taurine treatment performed well against oxidative stress in brain, increased the secretion of required hormones and protected against neuropathy, retinopathy and nephropathy in diabetes compared with the control. Taurine has been observed to be effective in treatments against diabetic hepatotoxicity, vascular problems and heart injury in diabetes. Taurine was shown to be effective against oxidative stress. The mechanism of action of taurine cannot be explained by one pathway, as it has many effects. Several of the pathways are the advanced glycation end-product pathway, PI3-kinase/AKT pathway and mitochondrial apoptosis pathway. The worldwide threat of diabetes underscores the urgent need for novel therapeutic measures against this disorder. Taurine (2-aminoethane sulfonic acid) is a natural compound that has been studied in diabetes and diabetes-induced complications.

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Abbreviations

DM:

Diabetes mellitus

Tau:

Taurine

LP:

Low protein

OLETF:

Long–Evans Tokushima fatty

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Authors and Affiliations

  1. School of Public Health, Dalian Medical University, Dalian, 116044, China

    Inam-u-llah, Fengyuan Piao, Kaixin Li, Mengren Zhang & Pingan Wu

  2. National Institute of Food Science and Technology, University of Agriculture Faisalabad, Faislabad, Pakistan

    Rana Muhammad Aadil

  3. Institute of Food Science and Technology, Graduate School of Chinese Academy of Agriculture Science, Beijing, China

    Raheel Suleman

  4. Department of Food Science and Technology, Muhammad Nawaz Sharif University of Agriculture, Multan, Pakistan

    Muhammad Shahbaz

  5. Department of Food Science and Technology, College of Environmental and Agricultural Sciences, Islamia University Bahawalpur, Bhawalpur, Pakistan

    Zulfiqar Ahmed

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Inam-u-llah, Piao, F., Aadil, R.M. et al. Ameliorative effects of taurine against diabetes: a review. Amino Acids 50, 487–502 (2018). https://doi.org/10.1007/s00726-018-2544-4

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