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Glutathione-Responsive T1 Contrast Agent for Tumor Imaging

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Abstract

Tumor microenvironment responsive probe holds great potential to achieve precise diagnosis owning to its capacity to show different signal in tumor and normal tissue. Here, we develop an intelligent magnetic resonance imaging (MRI) contrast agent (CA) with the capacity to rapidly respond to GSH. This intelligent MRI CA keep in “off” state in normal tissue while degrade into manganese ions and exhibit “on” state in tumor lesion. This unique feature endows this activable MRI CA to fulfill accurate tumor detection. Besides, this intelligent CA show negligible cytotoxicity to cell and mice, indicating its excellent biocompatibility and immense potential to biological application. This work develops a new activable MRI CA to sensitively detect tumor and provides guidelines to design new activable MRI CA for precise diagnosis.

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Data Availability

The data that support the findings of this study are available from the corresponding author on request.

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Funding

This work was supported by the Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau, 2019MSXM016).

Author information

Authors and Affiliations

  1. Department of Critical Care Medicine, Zhongxian People’s Hospital of Chongqing, Chongqing, 404399, China

    Xueqin Wang

  2. Department of Critical Care Medicine, The First Affiliated Hospital-Zhongxian Hospital of Chongqing Medical University, Chongqing, 404399, China

    Xueqin Wang & Hong Tang

  3. Department of Radiology, Zhongxian People’s Hospital of Chongqing, Chongqing, 404399, China

    Xi Ye & Yi Fu

  4. Department of Oncology, Zhongxian People’s Hospital of Chongqing, Chongqing, 404399, China

    Xiaoping Qin

  5. Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China

    Hong Tang

  6. Department of Surgical Intensive Care Unit, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China

    Hong Tang

Authors
  1. Xueqin Wang
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  2. Xi Ye
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  3. Xiaoping Qin
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  4. Yi Fu
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  5. Hong Tang
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Contributions

XW: conceptualization, methodology, data curation, formal analysis, investigation, writing—original draft. XY: data curation, formal analysis, investigation. XQ: data curation, formal analysis, investigation. YF: investigation. HT: conceptualization, methodology, data curation, formal analysis, writing—review and editing, funding acquisition.

Corresponding authors

Correspondence to Xueqin Wang or Hong Tang.

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Conflict of Interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Ethical Approval

Animal experiments were executed according to the protocol approved by Institutional Animal Care and Use Committee of Zhongxian People’s Hospital of Chongqing.

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Wang, X., Ye, X., Qin, X. et al. Glutathione-Responsive T1 Contrast Agent for Tumor Imaging. Appl Magn Reson 55, 387–397 (2024). https://doi.org/10.1007/s00723-023-01629-5

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  • DOI: https://doi.org/10.1007/s00723-023-01629-5

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