Abstract
Because of the toxicity of Gd(III) complexes and the poor T1 magnetic resonance imaging (MRI) contrast of superparamagnetic iron oxide, the development of new stable, non-toxic, and efficient contrast agents is desirable. Herein, tannic acid (TA), a large natural polyphenol, and bovine serum albumin (BSA) were used to construct non-toxic Fe(III) complexes with increased relaxivity based on a strategy slowing the molecular spin. Compared with the commercial T1 contrast agent Magnevist, TA-Fe@BSA not only exhibits comparable T1 MRI contrast enhancement under 0.5, 1 and 7 T magnetic fields both in vitro and in vivo, but also has better stability and biocompatibility. Moreover, TA-Fe@BSA with near-infrared (NIR) absorption demonstrates efficient tumor ablation via photothermal effects. These results demonstrate their strong potential as an alternative T1 MRI contrast agent and tumor theranostics agent in clinical settings.
摘要
Gd(III)配合物和超顺磁性氧化铁(SPION)是目前常见的T1MRI造影剂, 然而由于Gd(III)的毒性和SPION较差的对比度, 需要开发出新的稳定、 无毒的高效造影剂. 本论文基于减慢分子自旋的策略, 利用生物安全的天然多酚单宁酸和牛血清白蛋白来构建无毒的Fe(III)复合物TA-Fe@BSA. 该复合物具有良好的增强弛豫性能, 在溶液和体内测试中, 在0.5, 1和7 T磁场下均具有与商用T1 造影剂Magnevist®相当的T1 MRI增强造影效果, 而且具有良好的稳定性和生物相容性. 此外, 具有近红外吸收的TA-Fe@BSA基于其光热效应, 也表现出了有效的肿瘤消融作用. 这些结果证明了TA-Fe@BSA作为替代性T1 MRI造影剂和肿瘤治疗药物的潜力.
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Acknowledgements
This work was supported by the National Natural Science Foundation of China (91959105 and 21671135), Shanghai Sailing Program (19YF1436200), Shanghai Rising-Star Program (17QA1402600), Shanghai Talent Development Fund (2018082), and Shanghai Engineering Research Center of Green Energy Chemical Engineering (18DZ2254200).
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Author contributions An L analyzed the data and wrote the article; Cai Y carried out the experiments; Lin J participated in the discussion of the manuscript; Yang S and Tian Q supervised the project and were responsible for writing, editing and data curation. All authors contributed to the general discussion.
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Lu An received her Master degree from Shanghai Normal University in 2012. She is currently a PhD candidate under the supervision of Prof. Shiping Yang. Her research interest focuses on the development of multimodal imaging probes for theranostic applications.
Qiwei Tian obtained his PhD degree in materials science from Donghua University, China in 2012, and worked as a Postdoctoral Fellow at King Abdullah University of Science and Technology in 2012–2015. He is currently working as an associate professor at Shanghai Normal University and his research is focused on the development of smart agents for cancer theranostics.
Shiping Yang is a professor of the Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Normal University. He received his PhD degree in Sun Yat-sen University in 2000. His research interest is in the field of biomedical applications of nanomaterials for novel biomedical imaging and cancer therapy.
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Natural Polyphenols Tannic Acid Constructed Iron-Based Ultrasensitive Magnetic Resonance Contrast Agent for Tumor Theranostics
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An, L., Cai, Y., Tian, Q. et al. Ultrasensitive iron-based magnetic resonance contrast agent constructed with natural polyphenol tannic acid for tumor theranostics. Sci. China Mater. 64, 498–509 (2021). https://doi.org/10.1007/s40843-020-1434-1
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DOI: https://doi.org/10.1007/s40843-020-1434-1