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Correlation of Signal Intensity and ICP/OES-Related Concentration of Gadolinium-based Nanomagnetic Particles in Molecular MRI: In Vitro Study

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Abstract

Imaging methods have an important role in the management of patient’s health care. Some of the advantages made magnetic resonance imaging (MRI) as an exclusive modality. Gd-DTPA is one of the most common contrast agents in clinical applications. In this study, the concentrations of three gadolinium-based MRI contrast agents were measured and quantification accuracy of these contrast agents by MRI method was investigated. Different concentrations from the Gd-DTPA, Gd2O3–DEG and paramagnetoliposome nanoparticles (encapsulated Gd2O3–DEG nanoparticles in liposome) samples were prepared. Physical characteristics of the contrast agents were investigated by DLS and TEM methods. The T 1-weighted images of the prepared samples were recorded using MRI scanner. For each sample, gadolinium concentrations were determined using the relaxation rates and relaxivities. Determined concentrations by the experimental and ICP/OES methods were compared and the standard errors of the results were determined. Morphology, dimension and hydrodynamic diameter of the contrast agents were investigated. The hydrodynamic diameter of Gd2O3–DEG and PML nanoparticles were 90 ± 7.2 nm (with PdI = 0.328) and 96.8 ± 6.5 nm (with PdI = 0.299), respectively. In assessment of gadolinium concentrations, standard deviations of the experimental and ICP/OES data were ranged from 0.007 to 0.04. P values of all data points were higher than 0.05 that confirm there is no significant difference between the experimental and ICP/OES measurements. From the results, it could be concluded that MR systems could be used as an accurate and available method to estimate gadolinium concentrations.

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Acknowledgments

Our thanks to Food and Drug Laboratory Research Center and Imam Khomeini Hospital for their supports. Also, the authors appreciate Dr.Faraz Kalantari and Dr.Salman Zakariaee for the paper revision.

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Authors and Affiliations

  1. Medical Physics and Biomedical Engineering Department, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Banafsheh Nikfar, Nader Riyahi Alam & Sara Heydarnezhadi

  2. Pharmaceutical Department, Food and Drug Laboratory Research Center, Food and Drug Organization (FDO), Ministry of Health, Tehran, Iran

    Soheila Haghgoo & Ensiyeh Gorji

  3. Medical Imaging Center, Imam Hospital Complex, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Hossein Ghanaati & Behrooz Rafiei

  4. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Hossein Ghanbari

  5. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Mehdi Khoobi

  6. Medical Biomaterials Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Mehdi Khoobi

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  1. Banafsheh Nikfar
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  2. Nader Riyahi Alam
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  4. Hossein Ghanaati
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  7. Behrooz Rafiei
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  8. Ensiyeh Gorji
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  9. Sara Heydarnezhadi
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Correspondence to Nader Riyahi Alam.

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Nikfar, B., Riyahi Alam, N., Haghgoo, S. et al. Correlation of Signal Intensity and ICP/OES-Related Concentration of Gadolinium-based Nanomagnetic Particles in Molecular MRI: In Vitro Study. Appl Magn Reson 47, 77–86 (2016). https://doi.org/10.1007/s00723-015-0729-5

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  • DOI: https://doi.org/10.1007/s00723-015-0729-5

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