Abstract
A series of novel pyridine-annelated spirooxindole-3,2′-pyrrolidines was prepared via 1,3-cycloaddition reaction involving N-methylmaleimide as 1,3-dipolarophile and the appropriate azomethine ylide. The latter 1,3-dipolar species were generated in situ via decarboxylative condensation reaction of the particular α-amino acid with pyridine-annelated isatin in aqueous methanol under reflux. The structures of these new spirooxindole cycloadducts are based on microanalytical, spectral (IR, HRMS, and NMR), and X-ray crystal data.
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This research work has been supported financially by the Scientific Research Support Fund (SRSF/project number-mph/1/6/2011) at Amman, Jordan.
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Al-As’ad, R.M., El-Abadelah, M.M., Sabri, S.S. et al. A facile synthesis of novel pyridone-annelated spirooxindolepyrrolidines via 1,3-dipolar cycloaddition. Monatsh Chem 146, 621–629 (2015). https://doi.org/10.1007/s00706-014-1391-6
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DOI: https://doi.org/10.1007/s00706-014-1391-6