Skip to main content
Log in

Electroanalysis of antioxidants in pharmaceutical dosage forms: state-of-the-art and perspectives

  • Review
  • Published:
Monatshefte für Chemie - Chemical Monthly Aims and scope Submit manuscript

Abstract

Recent developments and future trends in electroanalytical chemistry of antioxidants in pharmaceutical dosage forms are discussed. The advantages of constant-current coulometry and different types of voltammetry in particular rapid response, sensitivity, selectivity, and low detection limits are demonstrated. The special attention is paid to various types of chemically modified electrodes including carbon nanomaterials, nanoparticles of metals, self-organized systems, and their combination. The data presented confirm that electroanalysis can be considered as alternative or additional technique to spectrophotometric and separation methods for determination of antioxidants in pharmaceuticals.

Graphical abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Mariani E, Polidori MC, Cherubini A, Mecocci P (2005) J Chromatogr B 827:65

    CAS  Google Scholar 

  2. Young IS, Woodside JV (2001) J Clin Pathol 54:176

    CAS  Google Scholar 

  3. Halliwell B, Gutteridge JMC (1999) Free radicals in biology and medicine. Oxford University Press, Oxford

    Google Scholar 

  4. Rice-Evans C, Miller NJ (1994) Methods Enzymol 234:279

    CAS  Google Scholar 

  5. Granot E, Kohen R (2004) Clin Nutr 23:3

    CAS  Google Scholar 

  6. Berry EM, Kohen R (1999) Med Hypotheses 53:397

    CAS  Google Scholar 

  7. Jodko K, Litwinienko G (2010) Postepy Biochem 56:248

    Google Scholar 

  8. Shimizu T, Nakanishi Y, Nakahara M, Wada N, Moro-Oka Y, Hirano T, Konishi T, Matsugo S (2010) J Clin Biochem Nutr 47:181

    CAS  Google Scholar 

  9. Marriage BJ, Clandinin MT, Macdonald IM, Glerum DM (2004) Mol Genet Metab 81:263

    CAS  Google Scholar 

  10. Storozhok NM, Drulle AIA, Login IAIA, Dregeris IAIA, Khrapova NG, Burlakova EB (1995) Vopr Med Khim 41:16

    CAS  Google Scholar 

  11. Hart JP (1990) Electroanalysis of biologically important compounds. Ellis Harwood, London

    Google Scholar 

  12. Wang J (2006) Analytical electrochemistry, 3rd edn. Wiley-VCH, New Jersey

    Google Scholar 

  13. Zoski CG (ed) (2007) Handbook of electrochemistry, 1st edn. Elsevier, Amsterdam

    Google Scholar 

  14. Dogan-Topal B, Ozkan SA, Uslu B (2010) Open Chem Biomed Methods J 3:56

    CAS  Google Scholar 

  15. Uslu B, Ozkan SA (2011) Anal Lett 44:2644

    CAS  Google Scholar 

  16. Cavalheiro ÉTG, Brett CMA, Oliveira-Brett AM, Fatibello-Filho O (2012) Bioanal Rev 4:31

    Google Scholar 

  17. Gupta VK, Jain R, Radhapyari K, Jadon N, Agarwal S (2012) Anal Biochem 408:179

    Google Scholar 

  18. Bonfilio R, De Araujo MB, Salgado HRN (2010) WSEAS Trans Biol Biomed 7:316

    CAS  Google Scholar 

  19. Milner GWC, Phillips G (1968) Coulometry in analytical chemistry. Pergamon Press, London

    Google Scholar 

  20. Watson DG (2012) Pharmaceutical analysis, 3rd edn. Elsevier Churchill Livingstone, Edinburgh

    Google Scholar 

  21. Abdullin IF, Chernysheva NN, Budnikov GK (2002) J Anal Chem 57:629

    CAS  Google Scholar 

  22. Abdullin IF, Chernysheva NN, Budnikov GK (2002) J Anal Chem 57:721

    CAS  Google Scholar 

  23. Shlyamina OV, Ziyatdinova GK, Abdullina SG, Budnikov GK (2007) J Anal Chem 62:957

    CAS  Google Scholar 

  24. Chernysheva NN, Abdullin IF, Budnikov GK (2001) J Anal Chem 56:663

    CAS  Google Scholar 

  25. Ziyatdinova GK, Samigullin AI, Abdullina SG, Budnikov GK (2008) Pharm Chem J 42:98

    CAS  Google Scholar 

  26. Ziyatdinova GK, Budnikov GK, Pogorel’tsev VI (2004) J Anal Chem 59:288

    CAS  Google Scholar 

  27. Ziyatdinova GK, Budnikov GK, Lapin AA (2007) J Anal Chem 62:260

    CAS  Google Scholar 

  28. Ziyatdinova GK, Budnikov HC (2007) Eurasian J Anal Chem 2:84

    CAS  Google Scholar 

  29. Ziyatdinova GK, Budnikov GK (2005) J Anal Chem 60:673

    CAS  Google Scholar 

  30. Ziyatdinova GK, Grigor’eva LV, Budnikov GK (2007) J Anal Chem 62:1176

    CAS  Google Scholar 

  31. Ziyatdinova GK, Budnikov GK (2005) Ukr Chem J 71:45

    CAS  Google Scholar 

  32. Ziyatdinova GK, Nizamova AM, Budnikov GK (2010) J Anal Chem 65:1176

    CAS  Google Scholar 

  33. Ziyatdinova G, Ziganshina E, Budnikov H (2012) Anal Chim Acta 744:23

    CAS  Google Scholar 

  34. Wang J (1988) Electroanalytical techniques in clinical chemistry and laboratory medicine. Wiley-VCH, New York

    Google Scholar 

  35. Guo W, Lin H, Liu L, Song J (2004) J Pharm Biomed Anal 34:1137

    CAS  Google Scholar 

  36. Acuna JA, De la Fuente C, Vazquez MD, Tascon ML, Gomez MI, Mata F, Batanero PS (2002) J Pharm Biomed Anal 29:617

    CAS  Google Scholar 

  37. Huang T, Gao P, Hageman MJ (2004) Curr Drug Discov Technol 1:173

    CAS  Google Scholar 

  38. Kissinger PT, Heineman WR (1996) Laboratory techniques in electroanalytical chemistry, 2nd edn. Marcel Dekker, New York

    Google Scholar 

  39. Smyth MR, Vos JG (1992) Analytical voltammetry, vol XXVII. Elsevier Science Pub, Amsterdam

    Google Scholar 

  40. Ozkan SA, Uslu B, Aboul-Enein HY (2003) Crit Rev Anal Chem 33:155

    Google Scholar 

  41. Bard AJ, Faulkner LR (2001) Electrochemical methods, fundamentals and applications, 2nd edn. Wiley-VCH, New York

    Google Scholar 

  42. Medvidović-Kosanović M, Šeruga M, Jakobek L, Novak I (2010) Collect Czech Chem Commun 75:547

    Google Scholar 

  43. Sokolová R, Degano I, Ramešová Š, Bulíčková J, Hromadová M, Gál M, Fiedler J, Valášek M (2011) Electrochim Acta 56:7421

    Google Scholar 

  44. Ramešová Š, Sokolová R, Degano I, Bulíčková J, Zabka J, Gál M (2012) Anal Bioanal Chem 402:975

    Google Scholar 

  45. Komorsky-Lovrić Š, Novak I (2009) Collect Czech Chem Commun 74:1467

    Google Scholar 

  46. Simić A, Manojlović D, Šegan D, Todorović M (2007) Molecules 12:2327

    Google Scholar 

  47. Corduneanu O, Janeiro P, Brett AMO (2006) Electroanalysis 18:757

    CAS  Google Scholar 

  48. Ramešová Š, Sokolová R, Tarábek J, Degano I (2013) Electrochim Acta 110:646

    Google Scholar 

  49. Janeiro P, Corduneanu O, Brett AMO (2005) Electroanalysis 17:1059

    CAS  Google Scholar 

  50. Aguirre MJ, Chen YY, Isaacs M, Matsuhiro B, Mendoza L, Torres S (2010) Food Chem 121:44

    CAS  Google Scholar 

  51. Janeiro P, Brett AMO (2005) Electroanalysis 17:733

    CAS  Google Scholar 

  52. Masek A, Chrzescijanska E, Zaborski M (2014) Food Chem 148:18

    CAS  Google Scholar 

  53. Ramešová Š, Degano I, Sokolová R (2014) Electrochim Acta 133:359

    Google Scholar 

  54. Lungu A, Sandu I, Boscornea C, Tomas S, Mihailciuc C (2010) Rev Roum Chim 55:109

    CAS  Google Scholar 

  55. Ziyatdinova GK, Gil’metdinova DM, Budnikov GK (2005) J Anal Chem 60:49

    CAS  Google Scholar 

  56. Ziyatdinova GK, Budnikov HC, Pogorel’tzev VI (2005) Anal Bioanal Chem 381:1546

    CAS  Google Scholar 

  57. Conners KA, Amidon GL, Kennon L (1986) Chemical stability of pharmaceuticals, 2nd edn. John Wiley & Sons, New York

    Google Scholar 

  58. Ziyatdinova G, Khuzina A, Budnikov H (2012) Anal Lett 45:1670

    CAS  Google Scholar 

  59. Barroso MF, Santos T, Sales MGF, Delerue-Matos C, Vaz MCVF (2007) Port Electrochim Acta 25:119

    CAS  Google Scholar 

  60. Ziyatdinova GK, Budnikov GK (2005) Pharm Chem J 39:447

    CAS  Google Scholar 

  61. Ziyatdinova GK, Budnikov GK (2005) Pharm Chem J 39:561

    CAS  Google Scholar 

  62. Mirel S, Oprean R, Mirel V, Sandulescu R (2008) Farmacia LVI:196

    Google Scholar 

  63. Barker GC, Gardner AW (1960) Fresenius Z Anal Chem 173:79

    CAS  Google Scholar 

  64. Hamann CH, Hamnett A, Vielstich W (2007) Electrochemistry, 2nd edn. Wiley-VCH, Weinheim

    Google Scholar 

  65. Hassan EM, Khamis EF, El-Kimary EI, Barary MA (2008) Talanta 74:773

    CAS  Google Scholar 

  66. Liu X, Lv H, Sun Q, Zhong Y, Zhao J, Fu J, Lin M, Wang J (2012) Anal Lett 45:2246

    CAS  Google Scholar 

  67. Uslu B, Özkan SA, Aboul-Enein HY (2002) Electroanalysis 14:736

    CAS  Google Scholar 

  68. Gu H-Y, Yu A-M, Chen H-Y (2001) Anal Lett 34:2361

    CAS  Google Scholar 

  69. Yilmaz S, Sadikoglu M, Saglikoglu G, Yagmur S, Askin G (2008) Int J Electrochem Sci 3:1534

    CAS  Google Scholar 

  70. Erdurak-Kiliç CS, Uslu B, Dogan B, Ozgen U, Ozkan SA, Coskun M (2006) J Anal Chem 61:1113

    Google Scholar 

  71. Michalkiewicz S (2008) Bioelectrochem 73:30

    CAS  Google Scholar 

  72. Song JF, He P, Guo W (2001) Anal Lett 34:1677

    CAS  Google Scholar 

  73. Mirceski V, Komorsky-Lovric S, Lovric M (2007) Square wave voltammetry. Theory and application. Springer-Verlag, Berlin

    Google Scholar 

  74. Adam V, Mikelova R, Hubalek J, Hanustiak P, Beklova M, Hodek P, Horna A, Trnkova L, Stiborova M, Zeman L, Kizek R (2007) Sensors 7:2402

    CAS  Google Scholar 

  75. Winter E, Codognoto L, Rath S (2007) Anal Lett 40:1197

    CAS  Google Scholar 

  76. Michalkiewicz S, Pryciak M, Malyszko J, Oszczudlowski J (2004) Electroanalysis 16:961

    CAS  Google Scholar 

  77. Zhang H, Xu L, Zheng J (2007) Talanta 71:19

    CAS  Google Scholar 

  78. Kellner R, Mermet JM, Otto M, Valcarcel M, Widmer HM (eds) (2004) Analytical chemistry: a modern approach to analytical science, 2nd edn. Wiley-VCH, Weinheim

    Google Scholar 

  79. Wang J, Tian B, Wang J, Lu J, Olsen C, Yarnitzky C, Olsen K, Hammerstrom D, Bennett W (1999) Anal Chim Acta 385:429

    CAS  Google Scholar 

  80. Gratteri P, Pinzauti S, Papeschi G, La Porta E, Furlanetto S (1992) Farmaco 47:695

    CAS  Google Scholar 

  81. Ioannides X, Economou A, Voulgaropoulos A (2003) J Pharm Biomed Anal 33:309

    CAS  Google Scholar 

  82. Ensafi AA, Hajian R (2008) J Braz Chem Soc 19:405

    CAS  Google Scholar 

  83. Ziyatdinova GK, Budnikov GK, Pogorel’tsev VI (2006) J Anal Chem 61:798

    CAS  Google Scholar 

  84. El-Shahawi MS, Bashammakh AS, El-Mogy T (2006) Anal Sci 22:1351

    CAS  Google Scholar 

  85. Abbasi S, Daneshfar A, Hamdghadareh S, Farmany A (2011) Intern J Electrochem Sci 6:4843

    CAS  Google Scholar 

  86. El-Desoky HS, Ghoneim MM (2011) Talanta 84:223

    CAS  Google Scholar 

  87. Zoulis NE, Efstathiou CE (1996) Anal Chim Acta 322:255

    Google Scholar 

  88. Temerk YM, Ibrahim MS, Kotb M (2011) J Braz Chem Soc 22:2056

    CAS  Google Scholar 

  89. Stradiotto NR, Yamanaka H, Zanoni MVB (2003) J Braz Chem Soc 14:159

    CAS  Google Scholar 

  90. Agűí L, Yáñez-Sedeño P, Pingarrón JM (2008) Anal Chim Acta 622:11

    Google Scholar 

  91. Huang J, Liu Y, You T (2010) Anal Meth 2:202

    Google Scholar 

  92. Fernández-Abedul MT, Costa-García A (2008) Anal Bioanal Chem 390:293

    Google Scholar 

  93. Gooding JJ (2005) Electrochim Acta 50:3049

    CAS  Google Scholar 

  94. Ziyatdinova G, Grigor’eva L, Morozov M, Gilmutdinov A, Budnikov H (2009) Microchim Acta 165:353

    CAS  Google Scholar 

  95. Welch CM, Compton RG (2006) Anal Bioanal Chem 384:601

    CAS  Google Scholar 

  96. Katz E, Willner I, Wang J (2004) Electroanalysis 16:19

    CAS  Google Scholar 

  97. Oyama M (2010) Anal Sci 26:1

    CAS  Google Scholar 

  98. Compton RG, Wildgoose GG, Rees NV, Streeter I, Baron R (2008) Chem Phys Lett 459:1

    CAS  Google Scholar 

  99. Swain GM (2004) Electroanalytical applications of diamond electrodes. In: Nebel CE, Ristein J (eds) Semiconductors and semimetals: thin-film diamond II. Elsevier, San Diego, p 121

    Google Scholar 

  100. Sarada BV, Terachima C, Ivandini TA, Rao TN, Fujishima A (2005) Electroanalytical applications of highly boron-doped diamond electrode. In: Fujishima A, Einaga Y, Rao TN, Tryk DA (eds) Diamond electrochemistry. Elsevier, Tokyo, p 261

    Google Scholar 

  101. Enache TA, Chiorcea-Paquim A-M, Fatibello-Filho O, Oliveira-Brett AM (2009) Electrochem Commun 11:1342

    CAS  Google Scholar 

  102. Vittal R, Gomathi H, Kim K-J (2006) Adv Colloid Interface Sci 119:55

    CAS  Google Scholar 

  103. Ziyatdinova G, Ziganshina E, Budnikov H (2012) Talanta 99:1024

    CAS  Google Scholar 

  104. Ziyatdinova G, Ziganshina E, Budnikov H (2013) Anal Meth 5:4750

    CAS  Google Scholar 

  105. Pramauro E, Pelizzetti E (1996) Surfactants in analytical chemistry. Applications of organized amphiphilic media. Elsevier Science, Amsterdam, New York

    Google Scholar 

  106. Ziyatdinova GK, Ziganshina ER, Budnikov HC (2012) J Anal Chem 67:869

    CAS  Google Scholar 

  107. Ziyatdinova G, Ziganshina E, Budnikov H (2014) Electrochim Acta 145:209

    CAS  Google Scholar 

  108. Agüí L, Manso J, Yáñez-Sedeño P, Pingarrón JM (2004) Talanta 64:1041

    Google Scholar 

  109. Tan WT, Goh JK (2008) Electroanalysis 20:2447

    CAS  Google Scholar 

  110. Ziyatdinova GK, Grigor’eva LV, Budnikov GK (2009) J Anal Chem 64:185

    CAS  Google Scholar 

  111. Pandey PC, Pandey AK, Hauhan DSC (2012) Electrochim Acta 74:23

    CAS  Google Scholar 

  112. Tan WT, Bond AM, Ngooi SW, Lim EB, Goh JK (2003) Anal Chim Acta 491:181

    CAS  Google Scholar 

  113. Suarez WT, Marcolino LH Jr, Fatibello-Filho O (2006) Microchem J 82:163

    Google Scholar 

  114. Ziyatdinova G, Giniyatova E, Budnikov H (2010) Electroanalysis 22:2708

    CAS  Google Scholar 

  115. Ziyatdinova G, Budnikov H (2012) J Solid State Electrochem 16:2441

    CAS  Google Scholar 

  116. Kondo T, Sakai K, Watanabe T, Einaga Y, Yuasa M (2013) Electrochim Acta 95:205

    CAS  Google Scholar 

  117. Jaiswal PV, Ijeri VS, Srivastava AK (2001) Anal Chim Acta 441:201

    CAS  Google Scholar 

  118. Ziyatdinova GK, Giniyatova ER, Budnikov HC (2012) J Anal Chem 67:467

    CAS  Google Scholar 

  119. Ziyatdinova G, Ziganshina E, Budnikov H (2013) J Solid State Electrochem 17:2679

    CAS  Google Scholar 

  120. Ziyatdinova G, Aytuganova I, Nizamova A, Morozov M, Budnikov H (2012) Collect Czech Chem Commun 76:1619

    Google Scholar 

  121. Xiao P, Zhao F, Zeng B (2007) Microchem J 85:244

    CAS  Google Scholar 

  122. Xiao P, Zhou Q, Xiao F, Zhao F, Zeng B (2006) Int J Electrochem Sci 1:228

    CAS  Google Scholar 

  123. Temerk YM, Ibrahim MS, Kotb M, Schuhmann W (2013) Electroanalysis 25:1381

    CAS  Google Scholar 

  124. Yin H, Zhou Y, Cui L, Liu T, Ju P, Zhu L, Ai S (2011) Microchim Acta 173:337

    CAS  Google Scholar 

  125. Song JC, Yang J, Zeng JF, Tan JA, Zhang L (2010) Microchim Acta 171:283

    CAS  Google Scholar 

  126. Tyszczuk K (2009) J Pharm Biomed Anal 49:558

    CAS  Google Scholar 

  127. Santos DP, Bergamini MF, Santos VAFFM, Furlan M, Zanoni MVB (2007) Anal Lett 40:3430

    CAS  Google Scholar 

  128. Sun W, Yang MX, Li YZ, Jiang Q, Liu SF, Jiao K (2008) J Pharm Biomed Anal 48:1326

    CAS  Google Scholar 

  129. Zhang Y, Zheng JB (2008) Talanta 77:325

    CAS  Google Scholar 

  130. Franzoi AC, Spinelli A, Vieira LC (2008) J Pharm Biomed Anal 47:973

    CAS  Google Scholar 

  131. Chen X, Wang Z, Zhang F, Zhu L, Li Y, Xia Y (2010) Chem Pharm Bull 58:475

    CAS  Google Scholar 

  132. Freitas KHG, Medeiros RA, Fatibello-Filho O (2009) Anal Lett 42:881

    Google Scholar 

  133. Freitas KHG, Fatibello-Filho O, de Mattos IL (2012) Braz J Pharm Sci 48:639

    CAS  Google Scholar 

  134. Zhou J, Zhang K, Liu J, Song G, Ye B (2012) Anal Methods 4:1350

    CAS  Google Scholar 

  135. Pınar PT, Yardım Y, Şentürk Z (2013) Cent Eur J Chem 11:1674

    Google Scholar 

  136. Yang S, Qu L, Li G, Yang R, Liu C (2010) J Electroanal Chem 645:115

    CAS  Google Scholar 

  137. Yu S-H, Zhao G-C (2011) Int J Electrochem 2012:431253

    Google Scholar 

  138. Sun D, Wang F, Wu K, Chen J, Zhou Y (2009) Microchim Acta 167:35

    CAS  Google Scholar 

  139. Kotkar RM, Srivastava AK (2006) Sens Actuators, B 119:524

    CAS  Google Scholar 

  140. Luo L, Wang X, Li Q, Ding Y, Jia J, Deng D (2010) Anal Sci 26:907

    CAS  Google Scholar 

  141. Wang L, Bai J, Huang P, Wang H, Zhang L, Zhao Y (2006) Electrochem Commun 8:1035

    CAS  Google Scholar 

  142. Pradha P, Mascarenhas RJ, Thomas T, Namboothiri INN, D’Souza OJ, Mekhalif Z (2014) J Electroanal Chem 732:30

    Google Scholar 

  143. Mazloum-Ardakani M, Taleat Z, Beitollahi H, Naeimi H (2011) Chin Chem Lett 22:705

    CAS  Google Scholar 

  144. Thomas T, Mascarenhas RJ, D’Souza OJ, Detriche S, Mekhalif Z, Martis P (2014) Talanta 125:352

    CAS  Google Scholar 

  145. Hu GZ, Zhang DP, Wu WL, Yang ZS (2008) Colloids Surf B 62:199

    CAS  Google Scholar 

  146. Goyal RN, Gupta VK, Bachheti N, Sharma R (2008) Electroanalysis 20:757

    CAS  Google Scholar 

  147. Zheng J, Zhou X (2007) Bioelectrochem 70:408

    CAS  Google Scholar 

  148. Shaidarova LG, Chelnokova IA, Gedmina AV, Budnikov GK (2009) J Anal Chem 64:36

    CAS  Google Scholar 

  149. Luo L-Q, Li Q-X, Ding Y-P, Zhang Y, Shen X (2010) J Solid State Electrochem 14:1311

    CAS  Google Scholar 

  150. Zhang H, Huang Q, Huang Y, Li F, Zhang W, Wei C, Chen J, Dai P, Huang L, Huang Z, Kang L, Hu S, Hao A (2014) Electrochim Acta 142:125

    CAS  Google Scholar 

  151. Lin KC, Tsai TH, Chen SM (2010) Biosens Bioelectron 26:608

    CAS  Google Scholar 

  152. Liu B, Luo L, Ding Y, Si X, Wei Y, Ouyang X, Xu D (2014) Electrochim Acta 142:336

    CAS  Google Scholar 

  153. Tyszczuk-Rotko K, Bȩczkowska I, Wójciak-Kosior M, Sowa I (2014) Talanta 129:384

    CAS  Google Scholar 

  154. Dalmasso PR, Pedano ML, Rivas GA (2012) Sens Actuat B 173:732

    CAS  Google Scholar 

Download references

Acknowledgments

This work was funded by the subsidy allocated to Kazan Federal University for the project part of state assignment in the sphere of scientific activities.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Guzel Ziyatdinova.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ziyatdinova, G., Budnikov, H. Electroanalysis of antioxidants in pharmaceutical dosage forms: state-of-the-art and perspectives. Monatsh Chem 146, 741–753 (2015). https://doi.org/10.1007/s00706-014-1376-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00706-014-1376-5

Keywords

Navigation