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Severe fever with thrombocytopenia syndrome virus genotype B in Thailand

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Abstract

Severe fever with thrombocytopenia syndrome virus (SFTSV) has been reported in many countries in Southeast Asia, which expands the original geographic range of China, Korea, and Japan. Here, we report the complete genome sequences of two Thai SFTSV strains previously identified in patients with undifferentiated febrile illness in 2020. Phylogenetically, both clustered with SFTSV genotype B strains and were most closely related to those previously reported in central China (≥99.0% nucleotide sequence identity) in the L, M, and S gene segments. Nine amino acid residues encoded by one or more Thai SFTSV genomes differed from those found in global strains. Interestingly, the observed differences in numerous residues between the Thai strains suggest possible separate introductions of different variants into the region.

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The nucleotide sequences of SFTSV strains in this study were deposited in the GenBank database under the accession numbers OQ341221-OQ341227.

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Acknowledgements

This work was funded by the Center of Excellence in Clinical Virology of the Faculty of Medicine of Chulalongkorn University and Hospital. PR, SK, and WC are supported by the Second Century Fund (C2F) of Chulalongkorn University.

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Authors and Affiliations

  1. Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

    Patthaya Rattanakomol, Sarawut Khongwichit, Watchaporn Chuchaona, Sompong Vongpunsawad & Yong Poovorawan

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  1. Patthaya Rattanakomol
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  2. Sarawut Khongwichit
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Correspondence to Yong Poovorawan.

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705_2023_5897_MOESM1_ESM.pdf

Supplementary file1 (PDF 894 KB) Supplementary Fig. S1 Additional phylogenetic analysis of the Thai SFTSV. (A) Partial M segment (549 nt). (B) Partial S segment (476 nt). The trees were generated using the maximum-likelihood method based on the Kimura 2-parameter model with 1,000 bootstrap replicates. Genotype assignments (A to F) were based on six distinct clusters with member strains identified by their GenBank accession number, country, and year of identification. Bootstrap values >70% are indicated at the branch nodes. The scale bar indicates the number of substitutions per site. Thai strains are shown with dots.

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Rattanakomol, P., Khongwichit, S., Chuchaona, W. et al. Severe fever with thrombocytopenia syndrome virus genotype B in Thailand. Arch Virol 168, 271 (2023). https://doi.org/10.1007/s00705-023-05897-1

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