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Genomic characterization of a fowl adenovirus serotype 4 strain isolated from a chicken with hydropericardium syndrome in Japan

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Abstract

Here, we report the genomic characterization of a fowl adenovirus serotype 4 strain isolated from a chicken with hydropericardium syndrome in Japan. The viral genome of FAdV-4 strain JP/LVP-1/96 was found to be 45,688 bp long. Amino acid substitutions at position 219 (G to D) in the fiber-2 protein and at position 188 (I to R) in the hexon protein, which are commonly found in virulent FAdV-4 strains, were also found in the JP/LVP-1/96 strain. Additional specific amino acid substitutions commonly found in virulent FAdV-4 strains were found in ORFs 4 and 43, which are present only in members of the species Fowl adenovirus C. Phylogenetic analysis based on complete hexon protein gene sequences showed that strain JP/LVP-1/96 belongs to a different genetic cluster from the strains circulating in neighboring countries.

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Funding

This study was conducted under the research project on “Regulatory research projects for food safety, animal health and plant protection (JPJ008617.17935709-2210)” funded by the Ministry of Agriculture, Forestry and Fisheries of Japan.

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Authors and Affiliations

  1. National Institute of Animal Health, National Agriculture and Food Research Organization (NARO), 3-1-5 Kannondai, Tsukuba, Ibaraki, 305-0856, Japan

    Masaji Mase, Hiroshi Iseki & Satoko Watanabe

  2. United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, Gifu, 501-1193, Japan

    Masaji Mase

  3. Kyoto Prefectural Chutan Livestock Hygiene Center, 371-2 Handa Fukuchiyama, Kyoto, 602-8570, Japan

    Yuko Tanaka

  4. Division of Zoonosis Research, National Institute of Animal Health, National Agriculture and Food Research Organization (NARO), 3-1-5 Kannondai, Tsukuba, Ibaraki, 305-0856, Japan

    Masaji Mase

Authors
  1. Masaji Mase
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  2. Yuko Tanaka
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  3. Hiroshi Iseki
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  4. Satoko Watanabe
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Contributions

 MM: designed the study. MM and YT: performed experiments. MM, YT, HI, and SW: wrote the manuscript

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Correspondence to Masaji Mase.

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The authors declare no competing financial interests.

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Mase, M., Tanaka, Y., Iseki, H. et al. Genomic characterization of a fowl adenovirus serotype 4 strain isolated from a chicken with hydropericardium syndrome in Japan. Arch Virol 167, 1191–1195 (2022). https://doi.org/10.1007/s00705-022-05390-1

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  • DOI: https://doi.org/10.1007/s00705-022-05390-1

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