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Molecular characteristics and phylogenetic analysis of novel goose parvovirus strains associated with short beak and dwarfism syndrome

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Abstract

Short beak and dwarfism syndrome (SBDS) emerged in Cherry Valley duck flocks in China in 2015, and novel goose parvovirus (NGPV) was shown to be the etiological agent of SBDS. To date, it is not known whether SBDS-related NGPV isolates possess common molecular characteristics. In this study, three new NGPV strains (namely, SDHT16, SDJN19, and SDLC19) were isolated from diseased ducks showing typical signs of SBDS and successfully passaged in embryonated goose or Cherry Valley duck eggs. The complete genome sequences of these NGPV strains were 98.9%–99.7% identical to each other but showed slightly less similarity (95.2%–96.1% identity) to classical GPV strains. A total of 16 common amino acid substitutions were present in the VP1 proteins of six NGPV strains (SDHT16, SDJN19, SDLC19, QH, JS1, and SDLC01) compared with the classical Chinese GPV strains, nine of which were identical to those found in European GPV strain B. The non-structural protein Rep1 of the six NGPV strains had 12 common amino acid substitutions compared with the classical GPV strains. Phylogenetic analysis indicated that the Chinese NGPV strains clustered with the European SBDS-related NGPV strains, forming a separate branch that was distinct from the group formed by the classical GPV strains. The present study shows the common molecular characteristics of NGPV isolates and suggests that the Chinese NGPV isolates probably share a common ancestor with European SBDS-related NGPV strains.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant numbers 31572551, 31172317) and by a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.

Funding

This work was supported by the National Natural Science Foundation of China (Grant numbers 31572551, 31172317) and by a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.

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Authors and Affiliations

  1. College of Veterinary Medicine, Yangzhou University, 48 Wenhui East Road, 225009, Yangzhou, China

    Yonglin Li, Jingyu Jia, Qingling Mi, Guoqiang Zhu & Jianye Wang

  2. Jiangsu Co-Innovation Center for Important Animal Infectious Diseases and Zoonosis, Yangzhou, Jiangsu, China

    Yonglin Li, Jingyu Jia, Qingling Mi, Guoqiang Zhu & Jianye Wang

  3. Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan, Shandong, China

    Yufeng Li & Yuehua Gao

Authors
  1. Yonglin Li
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  2. Jingyu Jia
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  3. Qingling Mi
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  4. Yufeng Li
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  5. Yuehua Gao
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  6. Guoqiang Zhu
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  7. Jianye Wang
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Contributions

YL, JJ, and QM carried out the overall experiments and analyzed the data. YL, and YG collected the tissue samples during the SBDS disease outbreak on Cherry Valley duck farms. YL, JJ wrote the paper. GZ helped to analyze the results and contributed to language polishing. JW conceived the project and directed the research.

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Correspondence to Jianye Wang.

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The authors declare that they have no competing interests.

Ethical approval

The procedure for inoculation of embryonated goose or duck eggs was approved by the Animal Care and Use Committee of Yangzhou University and performed in accordance with the ‘‘Guidelines for Experimental Animals’’ of the Ministry of Science and Technology (Beijing, China). No specific permissions were required for these locations/activities.

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Handling Editor: Sheela Ramamoorthy.

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Li, Y., Jia, J., Mi, Q. et al. Molecular characteristics and phylogenetic analysis of novel goose parvovirus strains associated with short beak and dwarfism syndrome. Arch Virol 166, 2495–2504 (2021). https://doi.org/10.1007/s00705-021-05145-4

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  • DOI: https://doi.org/10.1007/s00705-021-05145-4

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