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Sexual dysfunction in men with young onset Parkinson's disease

  • Neurology and Preclinical Neurological Studies - Original Article
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Abstract

Sexual dysfunction (SD) is a common, yet under-reported non-motor symptom of PD. Common sexual symptoms among male PD patients include erectile dysfunction, premature ejaculation, and decreased sexual desire. Few research papers have examined sexual dysfunction in PD, especially in YOPD male patients, and there is no Indian research study on sexual dysfunction in YOPD. In this study, we determined the frequency of sexual dysfunction in men with YOPD, and its correlation with other motor and NMS. This prospective cross-sectional study was conducted on YOPD males who presented to the Department of Neurology, NIMHANS, Bangalore, India, from May 2021 to April 2023. The diagnosis of YOPD was made based on MDS criteria for IPD 2015. Sexual functions were evaluated by ASEX, PEDT, QUIP-RS, and sex hormone assay. The patients also underwent other motor and non-motor assessments. Statistical analysis was done using SPSS version 22.0. The study was funded by the PDMD fund. This study included 62 male YOPD patients. The mean age of cases was 44.74 ± 8.54 years. The mean duration of symptoms was 8.45 ± 6.23 years. 43.5% of the cases of PD were Akinetic rigid type. By ASEX Score grading, 46.8% of the cases had erectile dysfunction and 71% of the cases of YOPD had premature ejaculation by PEDT Score grading. 9.7% of the cases had hypersexuality by QUIP-RS. Duration of YOPD was a better predictor of Erectile Dysfunction and premature ejaculation when compared with other variables. SD was related to anxiety and depression and it had a negative impact on the patient's health-related quality of life (HR-QoL). SD should be investigated and treated as an integral part of the neurological assessment in YOPD.

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Data Availability

The data will be made available on reasonable request to the corresponding author.

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Funding

NIMHANS PD FUND.

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Authors and Affiliations

  1. Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore, 560029, India

    M. Sandeep, Vikram V. Holla, Nitish Kamble, Rohan Mahale, Pramod Kumar Pal & Ravi Yadav

  2. Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore, 560029, India

    Shyam Sundar

Authors
  1. M. Sandeep
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  2. Shyam Sundar
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  3. Vikram V. Holla
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  4. Nitish Kamble
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  5. Rohan Mahale
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  6. Pramod Kumar Pal
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  7. Ravi Yadav
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Contributions

Conception and organization: RY, SM, and PKP. Execution of the study: RY, NK, SSA, NK, VVH, RM, and PKP. Statistical analysis: RY, SM, and VVH. Writing of first draft: RY, SM, and PKP. Review and critique: RY, NK, SS, NK, VH, RM, and PKP.

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Correspondence to Ravi Yadav.

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Informed consent was obtained from all the patients and controls included in the study.

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Sandeep, M., Sundar, S., Holla, V.V. et al. Sexual dysfunction in men with young onset Parkinson's disease. J Neural Transm 131, 149–155 (2024). https://doi.org/10.1007/s00702-023-02729-z

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