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Dispersive hierarchically porous composites based on defective MOFs as mixed-mode stationary phases for chromatographic separation

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Abstract

Defective metal–organic frameworks-based composites with excellent separation properties were obtained. The mesoporous metal–organic frameworks were selected and deliberately designed to be deficient, and they were then combined with polyacrylamide to be modified on the surface of silica microspheres. The prepared composites were employed as mixed-mode stationary phase in chromatographic separation, and they were compared to both conventional microporous metal–organic framework-based columns and commercial columns. It showed improved selectivity and retention toward both hydrophilic and hydrophobic analytes, allowing for the effective separation of nine nucleosides and nucleobases, eight alkaloids, six antibiotics, and five alkylbenzenes. Additionally, the column was used to effectively separate the active ingredients in the daring substance of honeysuckle, revealing a wide range of possible applications. For the same batch of analytes, three batches of distinct materials demonstrated consistent separation effects. It also demonstrated excellent chromatographic repeatability and stability, with relative standard deviations of the retention time and/or column efficiency being found to be less than 0.8% and 0.9%, respectively. The dispersive hierarchically porous composites were demonstrated to be effective in chromatographic separation, and the results expanded the potential uses of defective MOFs with dispersed multi-level pores.

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Funding

This work was supported by the Taishan Scholar Foundation of Shandong Province (Nos. tsqn202306189) and supported by the National Natural Science Foundation of China (Nos. 82304886), 72nd batch of China Postdoctoral Science Foundation (Nos. 2022M721999), Shandong Provincial Postdoctoral Support Foundation for Innovative Talents (Nos.SDBX2022019), Natural Science Foundation of Shandong Province (Nos.ZR2023QH210), Shandong Province Medical Health Science and Technology Development Plan Project (Nos. 202213030502), and Shandong TCM science and technology development project (Nos. Q-2023030).

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Authors and Affiliations

  1. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China

    Tiantian Si & Rong Rong

  2. Shandong Provincial Collaborative Innovation Center for Antiviral Traditional Chinese Medicine, Jinan, Shandong, 250355, China

    Rong Rong

  3. CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, Gansu, China

    Shuai Wang, Yong Guo & Xiaojing Liang

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  1. Tiantian Si
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  4. Xiaojing Liang
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Correspondence to Tiantian Si, Xiaojing Liang or Rong Rong.

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Si, T., Wang, S., Guo, Y. et al. Dispersive hierarchically porous composites based on defective MOFs as mixed-mode stationary phases for chromatographic separation. Microchim Acta 191, 198 (2024). https://doi.org/10.1007/s00604-024-06287-3

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