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Enantioseparation by zeolitic imidazolate framework-8-silica hybrid monolithic column with sulfobutylether-β-cyclodextrin as a chiral additive in capillary electrochromatography

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Abstract

A zeolitic imidazolate framework (ZIF)-8-silica hybrid monolithic column was prepared by one-step sol–gel method. The stationary phase in the monolithic column was characterized by Fourier-transform infrared spectra, X-ray diffraction, thermogravimetric analysis, nitrogen adsorption/desorption, and zeta potential. The results showed that ZIF-8-silica hybrid monolithic materials had abundant functional groups, good crystallinity, large specific surface area, and good thermal stability. A capillary electrochromatography (CEC) chiral separation system was for the first time constructed with ZIF-8-silica hybrid monolithic column and sulfobutylether-β-cyclodextrin (SBE-β-CD) as a chiral additive and was applied to separate the selected single and mixed chiral compounds (13 natural amino acids and 5 chiral pesticides). Under the optimized CEC conditions, all the single analytes achieved baseline separation with resolution of 2.14–5.94 and selectivity factor of 1.06–1.49 in less than 6 min, and the mixed amino acids with similar properties were also simultaneously enantioseparated (Rs ≥ 1.82). Relative standard deviations (RSDs) of migration time and column efficiency were lower than 4.26% and did not change significantly after 200 runs, evidencing excellent reproducibility and stability. These results demonstrate that the application of SBE-β-CD as a chiral additive for ZIF-8-silica hybrid monolithic columns is a promising method for the separation of chiral compounds.

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Funding

We gratefully acknowledge the support of the Fundamental Research Funds in Heilongjiang Provincial Universities (No. 145209501) and the second batch of Ministry of Education supply and demand docking employment and education projects.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, 161006, China

    Lidi Gao, Hongshou Cui, Xinyu Guo, Qing Dong, Xingyu You, Shili Qin & Lihua Jia

  2. College of Life Science, Northeast Agricultural University, Harbin, 150038, China

    Xinshu Guo

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  1. Lidi Gao
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L.D. Gao, S.L. Qin, and H.S. Cui contribute equally to this work.

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Correspondence to Shili Qin.

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The original online version of this article was revised: In this article, the wrong Fig. 3 has been introduced during production. Given here is the correct figure.

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Gao, L., Cui, H., Guo, X. et al. Enantioseparation by zeolitic imidazolate framework-8-silica hybrid monolithic column with sulfobutylether-β-cyclodextrin as a chiral additive in capillary electrochromatography. Microchim Acta 190, 315 (2023). https://doi.org/10.1007/s00604-023-05908-7

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