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Deep eutectic solvent synthesis of iron vanadate-decorated sulfur-doped carbon nanofiber nanocomposite: electrochemical sensing tool for doxorubicin

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Abstract

Detection of anticancer drug (doxorubicin) using an electrochemical sensor is developed based on a transition metal vanadate’s related carbon composite material. With an environmentally friendly process, we have synthesized a metal oxide composite of iron vanadate nanoparticle assembled with sulfur-doped carbon nanofiber (FeV/SCNF). The FeV/SCNF composite was characterized using XRD, TEM, FESEM with elemental mapping, XPS and EDS. In contrast to other electrodes reported in the literature, a much-improved electrochemical efficiency is shown by FeV/SCNF composite modified electrodes. Amperometric technique has been employed at 0.25 V (vs. Ag/AgCl) for the sensitive detection of DOX within a wide range of 20 nM–542.5 μM and it possesses enhanced selectivity in presence of common interferents. The modified electrochemical sensors show high sensitivity of 46.041 μA μM−1 cm−2. The newly developed sensor could be used for the determination of doxorubicin in both blood serum and drug formulations with acceptable results, suggesting its feasibility for real-time applications.

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Acknowledgements

This research was funded by the Deanship of Scientific Research at Princess Nourah Bbint Abdulrahman University through the Fast-track Research Funding Program.

Funding

This work was supported by the National Taipei University of Technology and MOST 107-2113-M-027-005 MY3, Ministry of Science and Technology, Taiwan.

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Authors and Affiliations

  1. Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Chung-Hsiao East Road, Section 3, Taipei, 10608, Taiwan, Republic of China

    Umamaheswari Rajaji & Shen-Ming Chen

  2. Department of Chemistry, School of Engineering and Technology, Jain University, Bangalore, 562112, India

    Yogesh Kumar K

  3. Department of Chemistry, New Horizon College of Engineering, Outer Ring Road, Bangalore, 560103, India

    M. S. Raghu & L. Parashuram

  4. Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, 11671, Saudi Arabia

    Fatimah Mohammed Alzahrani & Norah Salem Alsaiari

  5. Advanced Materials Research Chair, Chemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia

    Mohamed Ouladsmane

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  1. Umamaheswari Rajaji
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  2. Yogesh Kumar K
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Rajaji, U., K, Y.K., Chen, SM. et al. Deep eutectic solvent synthesis of iron vanadate-decorated sulfur-doped carbon nanofiber nanocomposite: electrochemical sensing tool for doxorubicin. Microchim Acta 188, 303 (2021). https://doi.org/10.1007/s00604-021-04950-7

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