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Bio-metal-organic frameworks for molecular recognition and sorbent extraction of hydrophilic vitamins followed by their determination using HPLC-UV

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Abstract

A bio-metal-organic framework (bio-MOF) derived from the amino acid L-serine has been prepared in bulk form and evaluated as sorbent for the molecular recognition and extraction of B-vitamins. The functional pores of bio-MOF exhibit high amounts of hydroxyl groups jointly directing other supramolecular host-guest interactions thus providing the recognition of B-vitamins in fruit juices and energy drinks. Single-crystal X-ray diffraction studies reveal the specific B-vitamin binding sites and the existence of multiple hydrogen bonds between these target molecules and the framework. It offered unique snapshots to accomplish an efficient capture of these solutes in complex aqueous matrices. Four B-vitamins (thiamin, nicotinic acid, nicotinamide, and pyridoxine) were investigated. They were eluted from the sorbent with phosphate buffer at pH 7 and analyzed by HPLC with UV detection. The sorbent was compared with commercial C18 cartridges. Following the procedure, acceptable reproducibility (RSD values < 14%) was achieved, and the detection limits were in the range 0.4 to 1.4 ng mL−1. The method was applied to the analysis of energy drink and juice samples and the recoveries were between 75 and 123% in spiked beverage samples.

A bio-MOF as SPE sorbent was prepared and applied to the extraction of B-vitamins in fruit juices and energy drinks.

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Funding

This work was supported by the Generalitat Valenciana (Project PROMETEO/2016/145), the Ministry of Science, Innovation and Universities (Spain) (Project RTI2018-095536-B-I00), the Ministero dell’Istruzione, dell’Università e della Ricerca (Italy) and the MINECO (Spain) (Projects CTQ2016–75671–P and Excellence Unit “Maria de Maeztu” MDM–2015–0538). H. M. Pérez-Cejuela thanks the MINECO for an FPU grant for PhD studies. Thanks are also extended to the “2019 Post–doctoral Junior Leader–Retaining Fellowship, la Caixa Foundation (ID100010434 and fellowship code LCF/BQ/PR19/11700011” (J. F.–S.), the Fondazione CARIPLO / “Economia Circolare: ricerca per un futuro sostenibile” 2019, Project code: 2019–2090, MOCA (D. A.), the Diamond Light Source for awarded beamtime and provision of synchrotron radiation facility and Drs. David Allan and Sarah Barnett for their assistance at I19 beamline (proposal number CY22411-1). E.P. acknowledges the financial support of the European Research Council under the European Union’s Horizon 2020 research and innovation programme / ERC Grant Agreement No 814804, MOF–reactors.

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Authors and Affiliations

  1. Department of Analytical Chemistry, University of Valencia, c/Dr. Moliner, 50, 46100, Valencia, Burjassot, Spain

    Héctor Martínez Pérez-Cejuela, Ernesto F. Simó-Alfonso & José Manuel Herrero-Martínez

  2. Department of Inorganic Chemistry, Institute of Molecular Science (ICMOL), University of Valencia, c/Catedrático José Beltrán 2, 46980, Valencia, Paterna, Spain

    Marta Mon, Jesús Ferrando-Soria & Emilio Pardo

  3. Dipartimento di Chimica e Tecnologie Chimiche (CTC), Università della Calabria, 87036, Rende, Cosenza, Italy

    Donatella Armentano

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  1. Héctor Martínez Pérez-Cejuela
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Correspondence to Emilio Pardo or José Manuel Herrero-Martínez.

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Pérez-Cejuela, H.M., Mon, M., Ferrando-Soria, J. et al. Bio-metal-organic frameworks for molecular recognition and sorbent extraction of hydrophilic vitamins followed by their determination using HPLC-UV. Microchim Acta 187, 201 (2020). https://doi.org/10.1007/s00604-020-4185-z

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