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A nanohybrid composed of polyoxotungstate and graphene oxide for dispersive micro solid-phase extraction of non-steroidal anti-inflammatory drugs prior to their quantitation by HPLC

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Abstract

A nanohybrid was prepared from polyoxotungstate anion and graphene oxide (POT/GO) and characterized in terms of porosity by applying Fourier transform infrared and transmission electron microscopy. The nanohybrid was applied as a sorbent for the dispersive micro solid-phase extraction of the non-steroidal anti-inflammatory drugs (NSAIDs) ibuprofen, diclofenac, and naproxen. Different types of sorbents were compared, and the POT/GO nanohybrid was found to have the best adsorption affinity. The NSAIDs were quantified via HPLC with UV detection. Under the optimum conditions, the limits of detection (at an S/N ratio of 3) range between 0.02–0.03 ng.mL−1, and the linear response ranges extend from 0.08–200 ng.mL−1, respectively. The relative standard deviations (RSDs) for five replicates at three concentration levels (0.1, 5 and 100 ng.mL−1) of NSAIDs ranged from 4.1 to 6.1%. The applicability of the method was confirmed by analyzing spiked real water samples, and satisfactory results were obtained, with recoveries between 95.6 and 99.6%.

Schematic representation of the polyoxotungstate/graphene oxide nanohybrid preparation.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, Hakim Sabzevari University, Sabzevar, 96179-76487, Iran

    Amirhassan Amiri

  2. Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, 91775-1436, Iran

    Masoud Mirzaei & Shadi Derakhshanrad

Authors
  1. Amirhassan Amiri
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  2. Masoud Mirzaei
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  3. Shadi Derakhshanrad
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Correspondence to Amirhassan Amiri or Masoud Mirzaei.

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Amiri, A., Mirzaei, M. & Derakhshanrad, S. A nanohybrid composed of polyoxotungstate and graphene oxide for dispersive micro solid-phase extraction of non-steroidal anti-inflammatory drugs prior to their quantitation by HPLC. Microchim Acta 186, 534 (2019). https://doi.org/10.1007/s00604-019-3694-0

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