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A hollow CuOx/NiOy nanocomposite for amperometric and non-enzymatic sensing of glucose and hydrogen peroxide

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Abstract

The authors report that CuOx/NiOy hollow nanocomposites are an effective bifunctional catalyst capable of oxidizing glucose and reducing hydrogen peroxide. Synthesis is based on a solvothermal process and subsequent thermal treatment. The structure can be controlled by adjusting the amounts of added NiCl2 during the solvothermal etching process, and core-shell, yolk-shell or hollow structures can be obtained. The porous hollow structure composite of type CuO30/NiO90 was used to modify a glassy carbon electrode. It exhibits excellent electrocatalytic activity towards glucose oxidation in solution of pH 13, typically at a working potential of +0.60 V (vs. Ag/AgCl). This enables voltammetric sensing of glucose with (a) a low limit of detection (0.08 μM, at S/N = 3), (b) over a wide linear range (0.20 μM - 2.5 mM), and (c) high sensitivity (2043 μA·mM−1·cm−2). The sensor is reproducible, selective and stable. It can be used to detect glucose in spiked human serum. The CuO30/NiO90 composite also displays good electrocatalytic activity towards reduction of H2O2 in neutral aqueous medium, typically at an applied potential of −0.35 V. It has a detection limit of 90 nM, a sensitivity of 271.1 μA·mM−1·cm−2, and a linear detection range that extends from 0.30 μM to 9.0 mM.

CuOx/NiOy nanocomposites with three different structures were synthesized by coordinated etching precipitation method. The hollow structure CuO30/NiO90 was coated on the surface of glassy carbon electrode for the amperometric determination of glucose and hydrogen peroxide.

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Acknowledgements

We gratefully acknowledge financial support from the National Natural Science Foundation of China (No. 21675147) and the Ministry of Science and Technology of China (No. 2016YFC1400601).

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Authors and Affiliations

  1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China

    Ling Long, Xiangjian Liu, Lulu Chen, Dandan Li & Jianbo Jia

  2. University of Science and Technology of China, Hefei, 230026, Anhui, China

    Ling Long, Xiangjian Liu, Lulu Chen & Jianbo Jia

  3. School of Chemical and Environmental Engineering, Wuyi University, Jiangmen, 529020, Guangdong, China

    Jianbo Jia

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  1. Ling Long
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  2. Xiangjian Liu
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  3. Lulu Chen
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Correspondence to Jianbo Jia.

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Long, L., Liu, X., Chen, L. et al. A hollow CuOx/NiOy nanocomposite for amperometric and non-enzymatic sensing of glucose and hydrogen peroxide. Microchim Acta 186, 74 (2019). https://doi.org/10.1007/s00604-018-3183-x

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