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Voltammetric dopamine sensor based on three-dimensional electrosynthesized molecularly imprinted polymers and polypyrrole nanowires

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Abstract

Three-dimensional structures comprising polypyrrole nanowires (PPyNWs) and molecularly imprinted polymer (MIP) were prepared by electropolymerization on the surfaces of a glassy carbon electrode (GCE). The modified GCE possesses both large surface area and good electrocatalytic activity for oxidizing dopamine (DA), and this leads to high sensitivity. The electropolymerized MIP has a large number of accessible surface imprints, and this makes the GCE more selective. Under optimal conditions and at a working voltage of typically 0.23 V (vs. SCE), the calibration plot is linear in the 50 nM to 100 μM DA concentration range, and the limit of detection is 33 nM. The sensor has been successfully applied to the analysis of DA in injections.

Schematic of a three-dimensional nanocomposite based dopamine sensing platform based on the use of a molecularly imprinted polymer and poly(pyrrole) nanowires. The modified polypyrrole nanowires and molecularly imprinted polymer endowed high electrocatalytic capacity and good selectivity for dopamine recognition, respectively.

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Acknowledgements

We greatly appreciate the support of the National Natural Science Foundation of China (21575003) and Foundation for Innovation Team of Bioanalytical Chemistry of Anhui Province.

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Authors and Affiliations

  1. College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241000, People’s Republic of China

    Ying Teng, Fen Liu & Xianwen Kan

  2. The Key Laboratory of Functional Molecular Solids, Ministry of Education, Wuhu, China

    Ying Teng, Fen Liu & Xianwen Kan

  3. Anhui Laboratory of Molecule-Based Materials, Anhui Key Laboratory of Chemo-Biosensing, Anhui Key Laboratory of Functional Molecular Solids, Wuhu, China

    Ying Teng, Fen Liu & Xianwen Kan

Authors
  1. Ying Teng
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  2. Fen Liu
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  3. Xianwen Kan
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Correspondence to Xianwen Kan.

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Ying Teng and Fen Liu Co-first authors

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Teng, Y., Liu, F. & Kan, X. Voltammetric dopamine sensor based on three-dimensional electrosynthesized molecularly imprinted polymers and polypyrrole nanowires. Microchim Acta 184, 2515–2522 (2017). https://doi.org/10.1007/s00604-017-2243-y

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  • DOI: https://doi.org/10.1007/s00604-017-2243-y

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