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Amperometric detection of chloramine-T based on its reaction with p-aminophenylboronic acid

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Abstract

The authors describe a method for amperometric determination of chloramine-T that is based on the indirect detection of chloramine-T by detecting p-quinone imine (p-QI) that is generated by oxidation of p-aminophenylboronic acid by chloramine-T. p-QI can be detected with excellent selectivity and at low potential by using a glassy carbon electrode. Hence, the method displays attractive features such as high sensitivity, wide detection range and excellent selectivity. The electrode has two linear responses in the 50 nM to 100 μM concentration range and a 6 nM detection limit. Compared to other electrochemical methods, this assay has a detection limit that is better by three orders of magnitude. The relative standard deviation is 3.4% for the determination of 10 μM of the medical chloramine-T sample, and the recovery of a samples containing chloramine-T at a level of 10 μM is 115%.

Highly sensitive electrochemical detection of chloramine-T is achieved based on the reaction of chloramine-T with p-aminophenylboronic acid with a detection limit of 6 nM.

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Acknowledgements

This project was kindly supported by the National Natural Science Foundation of China (No. 21475123), Jilin Provincial Science and Technology Department (No. 2015020403YY), Changchun city technology bureau (No. 14KG046), the Chinese Academy of Sciences (CAS)-the Academy of Sciences for the Developing World (TWAS) President’s Fellowship Programme, CAS-TWAS Postgraduate Fellowship and CAS President’s International Fellowship Initiative (PIFI).

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Authors and Affiliations

  1. School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun, 130022, China

    Pan Hui, Yunhui Li, Xiuyun Yang, Ying Gao & Jing Shao

  2. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China

    Pan Hui, Wenyue Gao & Guobao Xu

  3. University of Chinese Academy of Sciences, Chinese Academy of Sciences, No. 19A Yuquanlu, Beijing, 100049, China

    Wenyue Gao

  4. Faculty of Medicine and Health Sciences, University of Gitwe, 01 Nyanza, Rwanda

    Jacques Nsabimana

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  1. Pan Hui
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  2. Wenyue Gao
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  3. Jacques Nsabimana
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  4. Yunhui Li
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  5. Xiuyun Yang
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  7. Jing Shao
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Correspondence to Jing Shao or Guobao Xu.

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Hui, P., Gao, W., Nsabimana, J. et al. Amperometric detection of chloramine-T based on its reaction with p-aminophenylboronic acid. Microchim Acta 184, 687–691 (2017). https://doi.org/10.1007/s00604-016-2060-8

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  • DOI: https://doi.org/10.1007/s00604-016-2060-8

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