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Determination of bromhexine at a glassy carbon paste electrode using differential pulse voltammetry and flow injection analysis with amperometric detection

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Abstract

New electrochemical methods for the determination of bromhexine based on differential pulse voltammetry (DPV) and flow injection analysis with amperometric detection (FIA-ED) were developed using a glassy carbon paste electrode. Optimal supporting electrolyte for DPV measurement was methanol/Britton–Robinson buffer pH 9 (80:20, v/v). In the case of FIA-ED, optimal conditions were as follows: detection potential +1.1 V, flow rate 1.0 cm3 min−1, injected volume 0.1 cm3, and carrier solution methanol–ten times diluted B-R buffer of pH 9 (80:20, v/v). Detection limit was 2.0 × 10−6 mol dm−3 for DPV and 3.1 × 10−7 mol dm−3 for FIA-ED. The applicability of the newly developed methods was verified by the determination of bromhexine in pharmaceutical preparations (tablets of Bromhexin-EGIS and Bromhexin 8 BC).

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Acknowledgments

This work was performed under the framework of specific university research (SVV). Financial support from the Grant Agency of the Czech Republic (project P206/12/G151) is gratefully acknowledged.

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Authors and Affiliations

  1. UNESCO Laboratory of Environmental Electrochemistry, Department of Analytical Chemistry, Faculty of Science, University Research Centre UNCE „Supramolecular Chemistry“, Charles University in Prague, Albertov 6, 12843, Prague 2, Czech Republic

    Jan Mika, Andrea Nemeckova, Jiri Zima, Jiri Barek & Hana Dejmkova

  2. National School of Public Health, FIOCRUZ, Rua Leopoldo Bulhoes, 1480-Manguinhos, Rio de Janeiro, Brazil

    Josino C. Moreira

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  1. Jan Mika
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  2. Josino C. Moreira
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  3. Andrea Nemeckova
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  4. Jiri Zima
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  6. Hana Dejmkova
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Correspondence to Hana Dejmkova.

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Mika, J., Moreira, J.C., Nemeckova, A. et al. Determination of bromhexine at a glassy carbon paste electrode using differential pulse voltammetry and flow injection analysis with amperometric detection. Monatsh Chem 146, 1211–1215 (2015). https://doi.org/10.1007/s00706-015-1469-9

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  • DOI: https://doi.org/10.1007/s00706-015-1469-9

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