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Silver nanoparticles modified with thiomalic acid as a colorimetric probe for determination of cystamine

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An Erratum to this article was published on 27 December 2016

Abstract

The authors describe a colorimetric method for highly selective determination of cystamine using silver nanoparticles capped with thiomalic acid (TMA-AgNPs). The TMA-AgNPs exhibit a strong surface plasmon resonance absorption band at 395 nm. After the addition of cystamine to their yellow colloidal solution, the absorption maximum at 395 nm decreases gradually, and a new absorption peak appears at around 560 nm. This is accompanied by a color change, first to green and then to purple. The aggregation of NPs induced by cystamine is assumed to be due to the electrostatic interaction between capped NPs and cystamine. Aggregation was confirmed by UV–vis absorptiometry and transmission electron microscopy. A linear correlation was obtained between the ratio of absorbances at 560 and 395 nm and the cystamine concentration in the range between 0.2 μM and 10.0 μM. The limit of detection is 46 nM. The method was successfully applied to the determination of cystamine in spiked human serum and urine samples. Recoveries ranged between 94.0 % and 100.9 %, and relative standard deviations are <9.50 % (for n = 3).

A rapid and selective colorimetric method for detection of cystamine is described. The electrostatic interactions between positively charged cystamine-capped silver nanoparticles (AgNPs) and negatively charged thiomalic acid capped AgNPs leads to nanoparticle aggregation and a color change from yellow to green.

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Acknowledgments

The authors are grateful for the financial supports of this study from Department of Chemistry, Faculty of Science, University of Kurdistan, Sanandaj (2014). We would like to thank Prof. Cristina Nerin and her group, Department of Analytical Chemistry, University of Zaragoza, Zaragoza, Spain for helping to do TEM.

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  1. Department of Chemistry, Faculty of Science, University of Kurdistan, Iran, P.O. Box 416, 66177-15175, Sanandaj, Iran

    Somayeh Mohammadi & Gholamreza Khayatian

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  1. Somayeh Mohammadi
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  2. Gholamreza Khayatian
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Correspondence to Somayeh Mohammadi.

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An erratum to this article is available at http://dx.doi.org/10.1007/s00604-016-2056-4.

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Mohammadi, S., Khayatian, G. Silver nanoparticles modified with thiomalic acid as a colorimetric probe for determination of cystamine. Microchim Acta 184, 253–259 (2017). https://doi.org/10.1007/s00604-016-1991-4

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