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Exploring single nucleotide polymorphisms previously related to obesity and metabolic traits in pediatric-onset type 2 diabetes

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Abstract

Aims

To evaluate the association of 64 obesity-related polymorphisms with pediatric-onset type 2 diabetes and other glucose- and insulin-related traits in Mexican children.

Methods

Case–control and case–sibling designs were followed. We studied 99 patients with pediatric-onset type 2 diabetes, their siblings (n = 101) without diabetes, 83 unrelated pediatric controls and 137 adult controls. Genotypes were determined for 64 single nucleotide polymorphisms, and a possible association was examined between those genotypes and type 2 diabetes and other quantitative traits, after adjusting for age, sex and body mass index.

Results

In the case–pediatric control and case–adult control analyses, five polymorphisms were associated with increased likelihood of pediatric-onset type 2 diabetes; only one of these polymorphisms (CADM2/rs1307880) also showed a consistent effect in the case–sibling analysis. The associations in the combined analysis were as follows: ADORA1/rs903361 (OR 1.9, 95% CI 1.2; 3.0); CADM2/rs13078807 (OR 2.2, 95% CI 1.2; 4.0); GNPDA2/rs10938397 (OR 2.2, 95% CI 1.4; 3.7); VEGFA/rs6905288 (OR 1.4, 95% CI 1.1; 2.1) and FTO/rs9939609 (OR 1.8, 95% CI 1.0; 3.2). We also identified 16 polymorphisms nominally associated with quantitative traits in participants without diabetes.

Conclusions

ADORA/rs903361, CADM2/rs13078807, GNPDA2/rs10938397, VEGFA/rs6905288 and FTO/rs9939609 are associated with an increased risk of pediatric-onset type 2 diabetes in the Mexican population.

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Funding

This work was supported by a Mexican Federal Funds Grant (HIM 2014/041).

Author information

Authors and Affiliations

  1. Research Unit of Medicine Based on Evidence, Hospital Infantil de México Federico Gómez, Mexico City, Mexico

    América Liliana Miranda-Lora

  2. Medical Research Unit in Biochemistry, Hospital de Especialidades Centro Médico Nacional SXXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico

    Miguel Cruz & Jorge Gutiérrez

  3. Laboratory of Genomics, Genetics and Bioinformatics, Hospital Infantil de México Federico Gómez, Mexico City, Mexico

    Jesús Aguirre-Hernández

  4. Department of Endocrinology, Hospital Infantil de México Federico Gómez, Mexico City, Mexico

    Mario Molina-Díaz

  5. Department of Community Health Research, Hospital Infantil de México Federico Gómez, Mexico City, Mexico

    Samuel Flores-Huerta & Miguel Klünder-Klünder

  6. Research Committee, Latin American Society for Pediatric Gastroenterology, Hepatology and Nutrition (LASPGHAN), Mexico City, Mexico

    Miguel Klünder-Klünder

Authors
  1. América Liliana Miranda-Lora
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  2. Miguel Cruz
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  3. Jesús Aguirre-Hernández
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  4. Mario Molina-Díaz
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  5. Jorge Gutiérrez
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  6. Samuel Flores-Huerta
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  7. Miguel Klünder-Klünder
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Corresponding author

Correspondence to Miguel Klünder-Klünder.

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The authors declare no conflict of interest.

Human and animal rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments.

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Informed consent and assessment was obtained from all participants for being included in the study.

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Miranda-Lora, A.L., Cruz, M., Aguirre-Hernández, J. et al. Exploring single nucleotide polymorphisms previously related to obesity and metabolic traits in pediatric-onset type 2 diabetes. Acta Diabetol 54, 653–662 (2017). https://doi.org/10.1007/s00592-017-0987-9

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  • DOI: https://doi.org/10.1007/s00592-017-0987-9

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