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Comparison of the predictive values of MRI-based vertebral bone quality scores for the determination of osteoporosis in different diseases

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Abstract

Purpose

The study aimed to examine the consistency of vertebral bone quality (VBQ) scores for assessing osteoporosis across different etiologies and explore the predictive value of various VBQ scores for fragility vertebral fractures.

Methods

Patients with fragility fractures were matched by age and sex to patients with lumbar degeneration. VBQ scores were calculated in T1- and T2-weighted magnetic resonance imaging. Differential analysis of bone quality was performed based on etiology.

Results

A total of 96 inpatients were retrospectively enrolled. VBQT1 scores were only sensitive to osteoporotic bone in degenerative group (p < 0.01), failing to identify osteoporosis in fractured group (p > 0.05). For the degenerative group, the area under the curve (AUC) using the VBQT1 scores to differentiate osteoporosis was 0.72. After controlling the confounding variables, only VBQT2 scores were significantly higher in fractured group than degenerative group, with a greater AUC of 0.82 predicting fragility fractures. VBQT1 scores moderately correlated with femoral neck T-scores in degenerative group (r = −0.45, p < 0.01) but not in fractured group (r = −0.24, p > 0.05). VBQT2 scores were not associated with femoral neck T-scores (p > 0.05).

Conclusion

This study is the first to evaluate the effectiveness of VBQs scores in assessing osteoporosis post-fracture. Only non-fractured patients’ bone quality is fully susceptible to VBQT1 scores. While VBQT1 scores may not correlate with fragility fractures, VBQT2 scores present a viable alternative.

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Acknowledgements

Thank individuals who contributed to the study or manuscript preparation but who do not fulfill all the criteria of authorship.

Funding

The author(s) received no financial support for the research, authorship, and/or publication of this article.

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Author notes

  1. Lu Wang, Qian Deng and Bang Wang contributed equally to this work and should be considered as co-first authors.

Authors and Affiliations

  1. Postgraduate School, Dalian Medical University, Dalian, 116000, Liaoning, China

    Lu Wang, Bang Wang, Xing-Bin Li & Zhao-Rui Wang

  2. Department of Rehabilitation, Taizhou People’s Hospital Affiliated to Nanjing Medical University, Taizhou, 225300, Jiangsu, China

    Lu Wang

  3. Department of Orthopedics, Taizhou People’s Hospital Affiliated to Nanjing Medical University, Taizhou, 225300, Jiangsu, China

    Qian Deng, Bang Wang, Xing-Bin Li, Zhi-Jun Sha, Zhao-Rui Wang & Ai-Bing Huang

  4. Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu, China

    Qian Deng

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  1. Lu Wang
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  2. Qian Deng
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  3. Bang Wang
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Correspondence to Ai-Bing Huang.

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The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Ethical approval

The Human Investigation Committee (IRB) of Taizhou People’s Hospital Affiliated to Nanjing Medical University approved this retrospective study (IRB ID: KY202300201).

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Wang, L., Deng, Q., Wang, B. et al. Comparison of the predictive values of MRI-based vertebral bone quality scores for the determination of osteoporosis in different diseases. Eur Spine J 33, 1504–1510 (2024). https://doi.org/10.1007/s00586-024-08151-7

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  • DOI: https://doi.org/10.1007/s00586-024-08151-7

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