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Analysis of factors associated with patient-reported physical functioning scores at discharge of allogeneic hematopoietic stem cell transplantation patients: a cross-sectional study

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Abstract

Purpose

The purpose of this study was to clarify the independent factors related to patient-reported physical functioning (PF) scores at discharge of patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Methods

A total of 103 patients who underwent allo-HSCT were included in this cross-sectional study. As a screening method, a single regression analysis was conducted with the PF domain in the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 at discharge as the dependent variable, and body mass index, adverse events related to HSCT, and objective physical functions as independent variables. Multiple regression analysis was performed with PF as the dependent variable and variables that passed the screening by single regression analysis and confounders as independent variables.

Results

The mean PF score at discharge of the patients was 76.5 (standard deviation: 15.2). Based on the results of screening by the single regression analysis, length of stay, infections (+ / −), acute graft-versus-host disease grade, brief fatigue inventory score (BFI), knee extensor strength, and 6-min walk distance (6MWD) were included in the multiple regression analysis. BFI (B =  − 11.94, p < 0.001) and 6MWD (per 10 m) (B = 0.56, p = 0.001) were extracted as significant independent variables governing the PF at discharge in the multiple regression model (adjusted R2 = 0.59).

Conclusion

Higher exercise tolerance and lower fatigue in patients who underwent allo-HSCT were associated independently with patient-reported better PF scores at discharge.

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Data availability

The datasets during and/or analyzed during the current study available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Rehabilitation Unit, Kyoto University Hospital, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan

    Masanobu Murao, Ryota Hamada, Junsuke Miyasaka, Michiko Yoshida, Honami Yonezawa, Manabu Nankaku, Ryosuke Ikeguchi & Shuichi Matsuda

  2. Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan

    Tadakazu Kondo, Yasuyuki Arai, Junya Kanda & Akifumi Takaori-Kondo

  3. Department of Clinical Laboratory Medicine and Center for Research and Application of Cellular Therapy, Kyoto University, Sakyo-ku, Kyoto, Japan

    Yasuyuki Arai

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  1. Masanobu Murao
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Contributions

Conceptualization: Masanobu Murao, Ryota Hamada, Junsuke Miyasaka, Michiko Yoshida, and Honami Yonezawa; methodology: Masanobu Murao, Ryota Hamada, and Tadakazu Kondo; formal analysis and investigation: Masanobu Murao, Ryota Hamada, and Tadakazu Kondo; writing-original draft preparation: Masanobu Murao, Ryota Hamada, and Tadakazu Kondo; writing-review and editing: Masanobu Murao, Ryota Hamada, Tadakazu Kondo, Junsuke Miyasaka, Michiko Yoshida, Honami Yonezawa, Yasuyuki Arai, Junya Kanda, and Manabu Nankaku; supervision: Tadakazu Kondo, Yasuyuki Arai, Junya Kanda, Manabu Nankaku, Ryosuke Ikeguchi, Akifumi Takaori-Kondo, and Shuichi Matsuda.

Corresponding author

Correspondence to Masanobu Murao.

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This study was approved by the Institutional Review Board of Kyoto University Hospital conducted in accordance with the international ethical recommendations stated in the Japanese Good Clinical Practice Guidelines.

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Consent to publication was obtained by signature from each subject.

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Murao, M., Hamada, R., Kondo, T. et al. Analysis of factors associated with patient-reported physical functioning scores at discharge of allogeneic hematopoietic stem cell transplantation patients: a cross-sectional study. Support Care Cancer 29, 7569–7576 (2021). https://doi.org/10.1007/s00520-021-06323-5

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