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Health-related quality of life of children with pre-dialysis chronic kidney disease

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Abstract

Background

The goal of this study was to evaluate the quality of life (QOL) of Asian children with pre-dialysis chronic kidney disease (CKD) and to reveal the factors influencing the QOL of children with CKD.

Methods

We performed a cross-sectional study of the PedsQL 4.0 Generic Core Scale Module in the KNOW-PedCKD (KoreaN cohort study for Outcome in patients with Pediatric Chronic Kidney Disease) cohort, and compared the child self-reported and parent proxy-reported QOL of the pediatric cohort. From 2011 through 2016, a total of 376 children with CKD were enrolled after informed consent was obtained from parents or caregivers in seven pediatric nephrology centers.

Results

In parent proxy-reports, male patients had a better QOL than female patients in the Physical Functioning category. In child self-reports, male patients had better QOL than female patients in the Physical, Emotional, and School Functioning categories. According to CKD stage, there were significant differences in the QOL score in all categories of parent proxy-reports, and patients with higher CKD stage (lower glomerular filtration rate) had a worse QOL. Growth parameters showed a significantly positive correlation with the QOL score in all categories.

Conclusions

The QOL of children with predialysis CKD is affected by various factors, including sex, glomerular filtration rate (GFR), socio-economic status, existence of co-morbidities, anemia, growth retardation, and behavioral disorders. To improve their QOL, it is important to objectively understand the respective effects of these factors and attempt early intervention.

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Author information

Author notes

  1. Hee Sun Baek and Hee Gyung Kang contributed equally to this work

Authors and Affiliations

  1. Department of Pediatrics, Kyungpook National University Children’s Hospital, 807, Hoguk-ro, Buk-gu, Daegu, 41404, Republic of Korea

    Hee Sun Baek & Min Hyun Cho

  2. Department of Pediatrics, Seoul National University Children’s Hospital, Seoul, South Korea

    Hee Gyung Kang, Hyun Jin Choi, Hae Il Cheong & Il Soo Ha

  3. Department of Pediatrics, Jeju University Hospital, Jeju, South Korea

    Kyung Hee Han

  4. Department of Pediatrics, Pusan National University Children’s Hospital, Yangsan, South Korea

    Seong Heon Kim

  5. Department of Pediatrics, Samsung Medical Center, Seoul, South Korea

    Hee Yeon Cho

  6. Department of Pediatrics, Severance Children’s Hospital, Seoul, South Korea

    Jae Il Shin

  7. Department of Pediatrics, Asan Medical Center, Seoul, South Korea

    Young Seo Park & Joo Hoon Lee

  8. Department of Preventive Medicine, Seoul National University Hospital, Seoul, South Korea

    Joongyub Lee

  9. Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea

    Curie Ahn

Authors
  1. Hee Sun Baek
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  2. Hee Gyung Kang
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  3. Hyun Jin Choi
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  4. Hae Il Cheong
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  5. Il Soo Ha
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  6. Kyung Hee Han
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  7. Seong Heon Kim
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  8. Hee Yeon Cho
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  9. Jae Il Shin
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  10. Young Seo Park
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  11. Joo Hoon Lee
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  13. Curie Ahn
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  14. Min Hyun Cho
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Corresponding author

Correspondence to Min Hyun Cho.

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Funding

KNOW-PedCKD (trial registration: NCT02165878- ClinicalTrials.gov) was funded by grants 2011E3300300, 2012E3301100, 2013E3301600, 2013E3301601, and 2013E3301602 awarded by the Research of Korea Centers for Disease Control and Prevention after peer-review.

Ethical approval

This study was approved by the institutional review boards of the participating centers, namely Jeju University Hospital (Jeju, South Korea), Pusan National University Children’s Hospital (Yangsan, South Korea), Severance Children’s Hospital (Seoul, South Korea), Kyungpook National University Children’s Hospital (Daegu, South Korea), Seoul National University Children’s Hospital (Seoul, South Korea), Samsung Medical Center (Seoul, South Korea), and Asan Medical Center (Seoul, South Korea). Children with CKD aged <18 years were enrolled in this study after informed consent had been obtained from their parents or guardians.

Conflicts of interest

The authors declare that they have no conflicts of interest.

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Baek, H.S., Kang, H.G., Choi, H.J. et al. Health-related quality of life of children with pre-dialysis chronic kidney disease. Pediatr Nephrol 32, 2097–2105 (2017). https://doi.org/10.1007/s00467-017-3721-5

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  • DOI: https://doi.org/10.1007/s00467-017-3721-5

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