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Long-term outcomes of patients with recurrent squamous cell carcinoma of the esophagus undergoing salvage endoscopic resection after definitive chemoradiotherapy

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A Correction to this article was published on 13 May 2020

This article has been updated

Abstract

Background

Salvage endoscopic resection (ER) has been reported to be effective for patients with local failure of esophageal squamous cell carcinoma (ESCC) after definitive chemoradiotherapy (dCRT). This study aimed to evaluate the long-term outcomes of salvage ER for patients with local failure of ESCC and to identify risk factors associated with disease recurrence after salvage ER.

Methods

This study included 45 patients undergoing salvage ER after dCRT during 2000 to 2017. After ER, all patients were required to undergo surveillance esophagogastroduodenoscopy (EGD) once or twice every year, and a computed tomography (CT) examination was repeated every 3 to 6 months. We assessed short-term outcomes and long-term outcomes.

Results

Of the 45 patients in this study, the baseline clinical T stage before dCRT was T1 in 80%, 66% of the patients did not have nodal metastasis. The median time from CRT to the detection of local failure was 11 months (range 2–130 months). The en-bloc resection rate was 46%, and the R0 resection rate was 38%, respectively. Stricture occurred after salvage ER for one case, while adverse events such as bleeding or perforation and ER-related death did not occur. After a median observation period of 57 months, recurrence free survival at 3 years was 58%, overall survival was 72%, and disease specific survival was 81%. In multivariate analysis, clinical N stage before CRT was the only independent risk factor of recurrence after salvage ER (p = 0.04).

Conclusions

Salvage ER might be effective local treatment in patients with local failure after dCRT. For the patients with clinical N stage, frequent surveillance should be performed.

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Acknowledgements

We would like to thank Dr. Amar Manvar (Montefiore Medical Center, Bronx, NY) and Dr. Lady Katherine Mejía Pérez (Internal Medicine, Cleveland Clinic Foundation) for editing a draft of the manuscript.

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Authors and Affiliations

  1. Endoscopy Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Mai Ego, Seiichiro Abe, Yukihiro Nakatani, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Ichiro Oda & Yutaka Saito

  2. Gastrointestinal Oncology Division, National Cancer Center Hospital, Tokyo, Japan

    Ken Kato, Yoshitaka Honma & Narikazu Boku

  3. Radiation Oncology Division, National Cancer Center Hospital, Tokyo, Japan

    Jun Itami

  4. Esophageal Surgery Division, National Cancer Center Hospital, Tokyo, Japan

    Hiyoyuki Daiko

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  1. Mai Ego
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Correspondence to Seiichiro Abe.

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Drs. Mai Ego, Seiichiro Abe, Yukihiro Nakatani, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Ichiro Oda, Ken Kato, Yoshitaka Honma, Jun Itami, Hiyoyuki Daiko, Yutaka Saito, and Narikazu Boku have no conflicts of interest or financial ties to disclose.

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This article was updated to correct the ordering of the data in Table 6.

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Ego, M., Abe, S., Nakatani, Y. et al. Long-term outcomes of patients with recurrent squamous cell carcinoma of the esophagus undergoing salvage endoscopic resection after definitive chemoradiotherapy. Surg Endosc 35, 1766–1776 (2021). https://doi.org/10.1007/s00464-020-07571-y

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