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Salvage endoscopic submucosal dissection for recurrent esophageal squamous-cell carcinoma after definitive chemoradiotherapy

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Abstract

Although concurrent definitive chemoradiotherapy (CRT) is considered a standard treatment for unresectable esophageal carcinoma, CRT is associated with local failure (40–50%), and further interventions are needed in these cases. However, morbidity and mortality rates remain high among patients undergoing salvage esophagectomy for recurrent tumors. Here, we report a rare experience of salvage endoscopic submucosal dissection (ESD) for recurrent esophageal squamous-cell carcinoma (SCC) after definitive CRT. A 55-year-old male was diagnosed with unresectable advanced mid-thoracic esophageal SCC with lymph node metastases involving the trachea. After definitive CRT with cis-diamminedichloroplatinum (CDDP)/5-fluorouracil (5-FU) and 60 Gy irradiation was performed, complete response was obtained. However, a recurrent esophageal SCC was detected in the mid-thoracic esophagus on endoscopy performed 6 months after CRT. The tumor was resected en bloc using ESD without any complications. There was no recurrence for 4 months after ESD. Salvage ESD may be a safe and effective treatment for recurrent esophageal SCC after CRT.

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Acknowledgments

The authors thank Dr. Gautam Deshpande for refining our manuscript. The authors have no commercial associations that could be a conflict of interest in relation to the article and report that there are no disclosures relevant to this publication.

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Authors and Affiliations

  1. Department of Gastroenterology, St. Luke’s International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan

    Naoki Ishii & Yoshiyuki Fujita

  2. Department of Pathology, St. Luke’s International Hospital, Tokyo, Japan

    Koyu Suzuki

Authors
  1. Naoki Ishii
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  2. Koyu Suzuki
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  3. Yoshiyuki Fujita
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Correspondence to Naoki Ishii.

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Ishii, N., Suzuki, K. & Fujita, Y. Salvage endoscopic submucosal dissection for recurrent esophageal squamous-cell carcinoma after definitive chemoradiotherapy. Clin J Gastroenterol 4, 85–88 (2011). https://doi.org/10.1007/s12328-011-0203-3

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  • DOI: https://doi.org/10.1007/s12328-011-0203-3

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