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Plasma-derived extracellular vesicles transfer microRNA-130a-3p to alleviate myocardial ischemia/reperfusion injury by targeting ATG16L1

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Abstract

Extracellular vesicles (EVs) are implicated in myocardial ischemia/reperfusion (I/R) injury as modulators by shuttling diverse cargoes, including microRNAs (miRNAs). The current study was initiated to unravel the potential involvement of plasma-derived EVs carrying miR-130a-3p on myocardial I/R injury. Rats were induced with moderate endoplasmic reticulum stress, followed by isolation of plasma-derived EVs. Then, an I/R rat model and hypoxia/reoxygenation (H/R) cardiomyoblast model were established to simulate a myocardial I/R injury environment where miR-130a-3p was found to be abundantly expressed. miR-130a-3p was confirmed to target and negatively regulate autophagy-related 16-like 1 (ATG16L1) in cardiomyoblasts. Based on a co-culture system, miR-130a-3p delivered by EVs derived from plasma protected H/R-exposed cardiomyoblasts against H/R-induced excessive cardiomyoblast autophagy, inflammation, and damage, improving cardiac dysfunction as well as myocardial I/R-induced cardiac dysfunction and tissue injury. The mechanism underlying the functional role of EVs-loaded miR-130a-3p was found to be dependent on its targeting relation with ATG16L1. The protective action of EV-carried miR-130a-3p was further re-produced in a rat model serving as in vivo validation as evidenced by improved cardiac function, tissue injury, myocardial fibrosis, and myocardial infarction. Collectively, miR-130a-3p shuttled by plasma-derived EVs was demonstrated to alleviate excessive cardiomyoblast autophagy and improve myocardial I/R injury.

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Funding

This study was partially supported by the National Natural Science Foundation (Nos. 81860316 and 81660284) and Key project of Natural Science Foundation of Jiangxi Province (No.20212ACB206021).

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Authors and Affiliations

  1. Department of Radiology, The Second Affiliated Hospital of Nanchang University, Donghu District, Jiangxi Province, No. 1, Minde Road, 330006, Nanchang, People’s Republic of China

    Sisi Yu, Xuepei Tang, Tian Zheng, Shuhao Li, Haibo Ren, Hailong Wu, Fei Peng & Lianggeng Gong

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  1. Sisi Yu
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  2. Xuepei Tang
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  3. Tian Zheng
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  4. Shuhao Li
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  7. Fei Peng
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  8. Lianggeng Gong
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Contributions

S.S.Y., X.P.T., T.Z., and S.H.L. designed the study. H.B.R., H.L.W., F.P., and L.G.G. collated the data, designed and developed the database, carried out data analyses, and produced the initial draft of the manuscript. S.S.Y., X.P.T., T.Z., and S.H.L. contributed to drafting the manuscript. All authors have read and approved the final submitted manuscript.

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Correspondence to Lianggeng Gong.

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The experimental process was ratified by the ethics committee of the Second Affiliated Hospital of Nanchang University and all the study procedures involving animals were compliant with the “Guide for the Care and Use of Laboratory Animals” published by the US National Institutes of Health. Due measures were adopted to limit animals’ pain.

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The authors declare no competing interests.

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Yu, S., Tang, X., Zheng, T. et al. Plasma-derived extracellular vesicles transfer microRNA-130a-3p to alleviate myocardial ischemia/reperfusion injury by targeting ATG16L1. Cell Tissue Res 389, 99–114 (2022). https://doi.org/10.1007/s00441-022-03605-0

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