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SoxC transcription factors: multifunctional regulators of neurodevelopment

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Abstract

During development, generation of neurons is coordinated by the sequential activation of gene expression programs by stage- and subtype-specific transcription factor networks. The SoxC group transcription factors, Sox4 and Sox11, have recently emerged as critical components of this network. Initially identified as survival and differentiation factors for neural precursors, SoxC factors have now been linked to a broader array of developmental processes including neuronal subtype specification, migration, dendritogenesis and establishment of neuronal projections, and are now being employed in experimental strategies for neuronal replacement and axonal regeneration in the diseased central nervous system. This review summarizes the current knowledge regarding SoxC factor function in CNS development and disease and their promise for regeneration.

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Acknowledgments

This work was supported by grants from the German Research Foundation (LI 858/9-1 to D.C.L), the Bavarian Research Network “ForIPS”, the University Hospital Erlangen (IZKF grants E12, E16, and E21 to D.C.L.). A.K. and S.T. are members of the research training group 2162 “Neurodevelopment and Vulnerability of the Central Nervous System” of the Deutsche Forschungsgemeinschaft (DFG GRK2162/1). The authors declare no competing financial interests.

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  1. Atria Kavyanifar and Soeren Turan equal contribution

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  1. Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany

    Atria Kavyanifar, Soeren Turan & D. Chichung Lie

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  2. Soeren Turan
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  3. D. Chichung Lie
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Correspondence to D. Chichung Lie.

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Kavyanifar, A., Turan, S. & Lie, D.C. SoxC transcription factors: multifunctional regulators of neurodevelopment. Cell Tissue Res 371, 91–103 (2018). https://doi.org/10.1007/s00441-017-2708-7

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  • DOI: https://doi.org/10.1007/s00441-017-2708-7

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