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Creatinine levels in French children with Down syndrome up to ten years old

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Abstract

Assess creatinine levels in French children with Down syndrome (DS) on the basis of the relationship between creatinine levels and age. The study included 279 children with DS aged 0 to 10 years who had been regularly monitored between 2004 and 2021 in a single genetics department and who had had at least one creatinine measurement. The creatinine level curves were established by estimating the median and the quantiles of order 2.5 and 97.5% according to age. A Generalized Additive Model for Location, Scale, and Shape was used. The results showed higher creatinine levels in children with DS than in children from the general population.

   Conclusion: The present results allow to propose an original chart of creatinine levels according to age in French children with DS, which should help optimize their medical management and improve the early detection of renal diseases.

What is Known:

• Creatinine is a product of muscle breakdown and depends on muscle mass and children with Down syndrome have muscle and growth characteristics that differ from those of the general paediatric population.

• Serum creatinine values in Japanese children with DS are higher than those of children from the general Japanese population.

What is New:

• Creatinine values in French children with DS are higher than those of children from the general French population.

• The proposed original chart for creatinine values according to age, specifically designed for individuals up to 10 years old, should serve for further investigation, prevention, and follow-up of children with DS.

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Data Availability

The data used for the analysis can be provided upon reasonable request by any qualified investigator.

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Acknowledgements

We are grateful to the families for participating in the study. We thank the Hospices Civils de Lyon for the funding of this study.

Funding

Hospices Civils de Lyon , crédit d’intéressement.

Author information

Authors and Affiliations

  1. Hospices Civils de Lyon, Pôle Santé Publique, Service de Biostatistique et Bioinformatique, F-69003, Lyon, France

    Joanna Pautonnier & Muriel Rabilloud

  2. CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Évolutive, Équipe Biostatistique-Santé, F-69100, Villeurbanne, France

    Joanna Pautonnier & Muriel Rabilloud

  3. Universite Claude Bernard Lyon 1, F-69100, Villeurbanne, France

    Joanna Pautonnier, Laurence Derain Dubourg, Justine Bacchetta, Muriel Rabilloud & Damien Sanlaville

  4. Hospices Civils de Lyon, Hôpital Femme Mère Enfant, Service de Génétique, Bron, France

    Sylvie Goutte & Damien Sanlaville

  5. CNRS UMR 5305, Lyon, France

    Laurence Derain Dubourg

  6. Hospices Civils de Lyon, Hôpital E. Herriot, Service de Néphrologie, Dialyse, Hypertension et Exploration Fonctionnelle Rénale, F-69003, Lyon, France

    Laurence Derain Dubourg

  7. Centre de Référence des Maladies Rénales Rares, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 59 Boulevard Pinel, 69677, Bron Cedex, France

    Justine Bacchetta & Bruno Ranchin

  8. Faculté de Médecine Lyon Est, Université de Lyon, Lyon, France

    Justine Bacchetta

  9. INSERM, UMR 1033, Faculté de Médecine Lyon Est, Université de Lyon, Lyon, France

    Justine Bacchetta

  10. Faculté de Médecine Lyon Sud Charles Mérieux, Université de Lyon, Lyon, France

    Damien Sanlaville

  11. CNRS, INSERM, Physiopathologie et Génétique du Neurone et du Muscle, UMR5261, U1315, Institut NeuroMyoGène, 69008, Lyon, France

    Damien Sanlaville

Authors
  1. Joanna Pautonnier
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  2. Sylvie Goutte
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  3. Laurence Derain Dubourg
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  4. Justine Bacchetta
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  5. Bruno Ranchin
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  6. Muriel Rabilloud
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  7. Damien Sanlaville
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Contributions

All authors contributed to the study conception and design. Data collection was made by D.S. and S.G. The statistical analysis was performed by J.P. and M.R. The first draft of the manuscript was written by J.P. and all authors commented on it. All authors read and approved the content and submission of the final manuscript.

Corresponding author

Correspondence to Joanna Pautonnier.

Ethics declarations

Ethical approval

The study was approved by the local ethics committee IRB (Comité Scientifique et éthique des Hospices Civils de Lyon, number: 22_926) and by the national data protection agency (Commission nationale de l’informatique et des liberté, CNIL) in accordance with the reference methodology MR004 (number: 22_5926). This study was performed in line with the principles of the Declaration of Helsinki.

Consent to participate

All individual participants included in the study agreed to the use of their data for research and publication purposes.

Competing interests

The authors have no relevant financial or non-financial interests to disclose.

Additional information

Communicated by Gregorio Milani

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Pautonnier, J., Goutte, S., Dubourg, L.D. et al. Creatinine levels in French children with Down syndrome up to ten years old. Eur J Pediatr 183, 1953–1957 (2024). https://doi.org/10.1007/s00431-024-05460-3

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  • DOI: https://doi.org/10.1007/s00431-024-05460-3

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