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A study of oxidative stress in neonates delivered through meconium-stained amniotic fluid

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Abstract

To estimate the levels of malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OH-dG) in cord blood plasma of newborns born through meconium-stained amniotic fluid (MSAF) and also to find out the correlation between their levels with birth weight and gestation, we measured the cord blood plasma levels of MDA and 8-OH-dG in 59 newborns born through MSAF and 50 newborns born through clear liquor. The levels of cord blood plasma MDA and 8-OH-dG were significantly higher in full-term and late-preterm newborns born through MSAF. On further comparison, it was found that both full-term and late-preterm intrauterine growth restricted (IUGR) neonates had higher levels of these markers as compared to babies born as appropriate for gestational age (AGA) through MSAF. Plasma levels of MDA and 8-OH-dG were significantly correlated with birth weight even after controlling the relationship with gestational age for all cases as well as all full-term cases. These markers are also significantly correlated to each other.

Conclusions: The present study suggest that the neonates born through MSAF experience higher degrees of oxidative stress, as evidenced by increased levels of cord blood plasma MDA and 8-OH-dG.

What is known:

• Aspirated meconium has been found to induce free radical generation and cellular damage in animal studies.

• Its role in free radical generation and oxidative damage in human neonates is scarce.

What is new:

• Neonates born through meconium-stained amniotic fluid experience significant oxidative stress.

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Abbreviations

8-OH-dG:

8-Hydroxy-2-deoxyguanosine

AGA:

Appropriate for gestational age

IUGR:

Intrauterine growth retardation

MAS:

Meconium aspiration syndrome

MDA:

Malondialdehyde

MSAF:

Meconium-stained amniotic fluid

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Institute of Medical Sciences, B.H.U, Vanarasi, India

    Tapas Bandyopadhyay & B. D. Bhatia

  2. Department of Biophysics, Institute of Medical Sciences, B.H.U, Vanarasi, India

    H. D. Khanna

Authors
  1. Tapas Bandyopadhyay
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  2. B. D. Bhatia
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  3. H. D. Khanna
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Correspondence to Tapas Bandyopadhyay.

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Communicated by Patrick Van Reempts

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Bandyopadhyay, T., Bhatia, B.D. & Khanna, H.D. A study of oxidative stress in neonates delivered through meconium-stained amniotic fluid. Eur J Pediatr 176, 317–325 (2017). https://doi.org/10.1007/s00431-016-2845-0

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  • DOI: https://doi.org/10.1007/s00431-016-2845-0

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