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Idiopathic Fetal Growth Restriction: Repercussion of Modulation in Oxidative Stress

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Abstract

Oxidative stress has been proposed as one of the causes involved in idiopathic fetal growth restriction (IFGR). However, the exact relationship between oxidative stress and IFGR is not understood. This study aimed at understanding the role of oxidative stress and antioxidant status in IFGR materno-fetal dyads and matched controls. 75 materno-fetal dyads with IFGR were enrolled with equal number of normal low risk controls. Malondialdehyde (MDA) levels were measured as marker of oxidative stress, while paraoxonase-1 (PON1) activity and total antioxidant capacity (TAC) of serum were measured as markers of antioxidant status. MDA levels were increased in both maternal and cord blood of IFGR neonates as compared to controls (p < 0.001). TAC of serum were found to be decreased in IFGR (both maternal and cord blood) as compared to controls (p < 0.001; p < 0.05, respectively). PON1 activity was found to be decreased in the IFGR mothers while it was found increased in IFGR cord blood (p < 0.01; p < 0.001)). IFGR is a state of increased oxidative stress. Decreased PON1 enzymatic activity in mothers is also associated with IFGR.

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Acknowledgments

The authors are thankful to the Indian Council for Medical Research, New Delhi and University College of Medical Sciences, Delhi for providing support in the form of research grant for completion of this work.

Conflict of interest

The authors declare that there is no conflict of interests regarding the publication of this paper.

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Authors and Affiliations

  1. Department of Biochemistry, University College of Medical Sciences and G T B Hospital, Dilshad Garden, Delhi, 110095, India

    Nilesh Chandra, Mohit Mehndiratta, B. D. Banerjee & A. K. Tripathi

  2. Department of Obstetrics & Gynecology, University College of Medical Sciences and G T B Hospital, Dilshad Garden, Delhi, 110095, India

    K. Guleria

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  1. Nilesh Chandra
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  2. Mohit Mehndiratta
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  3. B. D. Banerjee
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Correspondence to A. K. Tripathi.

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Chandra, N., Mehndiratta, M., Banerjee, B.D. et al. Idiopathic Fetal Growth Restriction: Repercussion of Modulation in Oxidative Stress. Ind J Clin Biochem 31, 30–37 (2016). https://doi.org/10.1007/s12291-015-0487-z

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  • DOI: https://doi.org/10.1007/s12291-015-0487-z

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