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Regional cerebellar volumetric correlates of manual motor and cognitive function

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Abstract

Cerebellar volume declines with aging. Few studies have investigated age differences in regional cerebellar volume (RCV) and their association with motor and cognitive function. In 213 healthy older adults, we investigated the association of age with motor skills, cognition and RCV. Subsequently, we studied the association of RCV with motor skills and cognition. RCVs were derived from T1-weighted MRI scans using the automated SUIT segmentation method and clustered using principal component analysis (PCA). Motor skill (manual dexterity, tapping speed, bimanual visuomotor coordination, grip force) and cognition (mental rotation, verbal memory, inhibition, mental flexibility) were assessed. Behavioral measures were clustered into compounds using PCA: left hand motor skill, right hand motor skill, verbal memory and mental flexibility, and mental rotation & inhibition. Volume of the rostral middle frontal gyri (rMFG) and premotor areas (PMA) were related to performance for reference. Analyses were adjusted for age, sex, and education. Volume of the cerebellar anterior lobe and top of the superior posterior lobe were positively associated with motor skill. Volume of the bottom part of the posterior superior lobe and the inferior posterior lobe was positively associated with cognition. PMA volume was associated with cognition and motor skill and rMFG volume with motor skill. Although these results did not survive FDR correction, their effect sizes suggest that regional cerebellar volume selectively contributes to cognitive and motor skill. Effect sizes of cerebellar associations with performance were similar to those of rMFG/PMA and performance suggesting parallel contributions to performance.

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Acknowledgments

VK was supported by a grant from the National Space Biomedical Research Institute (PF04101). YYH would like to thank the Stichting Fonds Dr. Catharine van Tussenbroek for their financial support. SM, SH and LJ are supported by the Velux-Stiftung (Project No. 369). This work was further supported by the University Research Priority Program (URPP) “Dynamics of Healthy Aging” of the University of Zurich. RS and LJ are members of the LIFE Course: Evolutionary and Ontogenetic Dynamics.

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    Authors and Affiliations

    1. School of Kinesiology, University of Michigan, 4745D Central Campus Recreation Building, 401 Washtenaw Avenue, Ann Arbor, MI, 48109, USA

      Vincent Koppelmans, Yoo Young Hoogendam & Rachael D. Seidler

    2. International Normal Aging and Plasticity Imaging Center (INAPIC), University of Zurich, Zurich, Switzerland

      Sarah Hirsiger, Susan Mérillat & Lutz Jäncke

    3. University Research Priority Program “Dynamics of Healthy Aging”, University of Zurich, Zurich, Switzerland

      Sarah Hirsiger, Susan Mérillat & Lutz Jäncke

    4. Division of Neuropsychology, University of Zurich, Zurich, Switzerland

      Lutz Jäncke

    5. Department of Special Education, King Abdulaziz University, Jeddah, Saudi Arabia

      Lutz Jäncke

    6. Department of Psychology, University of Michigan, Ann Arbor, USA

      Rachael D. Seidler

    7. Neuroscience Program, University of Michigan, Ann Arbor, USA

      Rachael D. Seidler

    8. Institute of Gerontology, University of Michigan, Ann Arbor, USA

      Rachael D. Seidler

    Authors
    1. Vincent Koppelmans
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    2. Yoo Young Hoogendam
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    3. Sarah Hirsiger
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    4. Susan Mérillat
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    5. Lutz Jäncke
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    6. Rachael D. Seidler
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    Corresponding author

    Correspondence to Rachael D. Seidler.

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    Conflict of interest

    All authors declare that the here-described research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

    Additional information

    V. Koppelmans and Y. Y. Hoogendam contributed equally.

    L. Jäncke and R. D. Seidler contributed equally.

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    Cite this article

    Koppelmans, V., Hoogendam, Y.Y., Hirsiger, S. et al. Regional cerebellar volumetric correlates of manual motor and cognitive function. Brain Struct Funct 222, 1929–1944 (2017). https://doi.org/10.1007/s00429-016-1317-7

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    • DOI: https://doi.org/10.1007/s00429-016-1317-7

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